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帕金森病靶点Nurr1以及Nurr1-RXRα别构激活的结构基础
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中国科学院广州生物医药与健康研究院刘劲松课题组近日解析了Nurr1多结构域结合DNA的结构，是核受体领域第一个单体多结构域晶体结构，并进一步利用整合结构生物学方法研究了Nurr1受DNA和配体RXRα调控的分子机制。相关研究成果以Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXRα heterodimer为题发表在PNAS上。https://www.ebiotrade.com/newsf/2022-12/20221208065256280.htm
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