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炎症性肠病中性粒细胞功能 研究主题

已有 417 次阅读 2022-12-5 08:25 |个人分类:消化系统|系统分类:科研笔记





Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease

https://pubmed.ncbi.nlm.nih.gov/34494943/

研究主题如下

MeSH terms

  • Animals

  • Butyrates / metabolism

  • Butyrates / pharmacology*

  • Cells, Cultured

  • Colitis / drug therapy

  • Colitis / microbiology

  • Colitis / pathology

  • Cytokines / analysis

  • Disease Models, Animal

  • Extracellular Traps / immunology*

  • Gastrointestinal Microbiome / physiology

  • Histone Deacetylase Inhibitors / pharmacology

  • Histone Deacetylases / metabolism

  • Homeostasis / immunology

  • Host Microbial Interactions / physiology

  • Humans

  • Hydroxamic Acids / pharmacology

  • Immunity, Innate / immunology

  • Inflammatory Bowel Diseases / drug therapy*

  • Inflammatory Bowel Diseases / microbiology

  • Inflammatory Bowel Diseases / pathology

  • Intestinal Mucosa / microbiology

  • Intestinal Mucosa / pathology*

  • Male

  • Mice

  • Mice, Inbred C57BL

  • Neutrophil Infiltration / drug effects*

  • Neutrophils / immunology*

  • Oxidative Stress / immunology

  • Pertussis Toxin / pharmacology

  • Receptors, G-Protein-Coupled / antagonists & inhibitors

Substances

  • Butyrates

  • Cytokines

  • Histone Deacetylase Inhibitors

  • Hydroxamic Acids

  • Receptors, G-Protein-Coupled

  • trichostatin A

  • Pertussis Toxin

  • Histone Deacetylases

Related information

Grant support

This work was supported by grants from the National Key R&D Program of China (2018YFC1705405) and the National Natural Science Foundation of China (grant number 81630017, 91942312);

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