许培扬博客分享 http://blog.sciencenet.cn/u/xupeiyang 跟踪国际前沿 服务国内科研

博文

诺奖发现 镰状细胞贫血

已有 837 次阅读 2022-9-25 14:48 |个人分类:诺贝尔奖|系统分类:论文交流



Stuart H.   Orkin,美国哈佛医学院David G. Nathan特聘儿科教授、霍华德·休斯医学研究所研究员

获奖原因:对血液病遗传基础展开基础性研究,以及推进镰状细胞贫血症和β-地中海贫血症的基因治疗

https://news.sciencenet.cn/htmlnews/2022/9/486641.shtm


https://pubmed.ncbi.nlm.nih.gov/34779027/


Am J Hematol

2022 Feb 1;97(2):168-170.

 doi: 10.1002/ajh.26407. Epub 2021 Nov 20.

Nobel prize in physiology or medicine 2021, receptors for temperature and touch: Implications for hematology

Immacolata Andolfo 1 2Seth L Alper 3Achille Iolascon 1 2

Affiliations expand

Free PMC article

No abstract available

Conflict of interest statement

Immacolata Andolfo and Achille Iolascon declare no conflict of interest. Seth L. Alper is a consultant for and receives research support from Quest Diagnostics, Inc.

Figures

FIGURE 1

FIGURE 1 

Schematic representation of PIEZO1 and…

Similar articles

See all similar articles

Cited by

References


    1. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat‐activated ion channel in the pain pathway. Nature. 1997;389:816‐824. - PubMed


    1. Coste B, Mathur J, Schmidt M, et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science. 2010;330:55‐60. - PMC PubMed


    1. Hillery CA, Kerstein PC, Vilceanu D, et al. Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease. Blood. 2011;118(12):3376‐3383. - PMC PubMed


    1. Xu C, Gulinello M, Frenette PS. Nociceptors protect sickle cell disease mice from vaso‐occlusive episodes and chronic organ damage. J Exp Med. 2021;218(1):e20200065. - PMC PubMed


    1. Zarychanski R, Schulz VP, Houston BL, et al. Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. Blood. 2012;120:1908‐1915. - PMC PubMed

Show all 17 references

MeSH terms

  • Anemia, Sickle Cell / metabolism*

  • Animals

  • Calcium / metabolism

  • Hematology

  • Humans

  • Ion Channels / metabolism

  • Nobel Prize

  • TRPV Cation Channels / metabolism

  • Temperature

  • Thermosensing*

  • Touch*

Substances

  • Ion Channels

  • PIEZO1 protein, human

  • PIEZO2 protein, human

  • TRPV Cation Channels

  • TRPV1 protein, human

  • Calcium

Related information

LinkOut - more resources


http://www.pubmedplus.cn/P/SearchQuickResult?wd=5e8475bc-6ef1-4902-b86e-a71f42860bb6

01.20221 篇14.286%
02.20201 篇14.286%
03.20181 篇14.286%
04.20171 篇14.286%
05.20061 篇14.286%
06.20041 篇14.286%
07.19991 篇14.286%
01.am j hematol1 篇14.286%
02.anal biochem1 篇14.286%
03.j appl physiol (1985)1 篇14.286%
04.mol aspects med1 篇14.286%
05.nature1 篇14.286%
06.perspect biol med1 篇14.286%
07.science1 篇14.286%
01.美国3 篇42.857%
02.丹麦1 篇14.286%
03.瑞典1 篇14.286%
04.瑞士1 篇14.286%
05.意大利1 篇14.286%
没有聚类出数据
01.Anemia, Sickle Cell6 篇85.714%
02.Humans6 篇85.714%
03.Animals4 篇57.143%
04.Nobel Prize3 篇42.857%
05.Cardiovascular Diseases2 篇28.571%
06.Cystic Fibrosis2 篇28.571%
07.Female2 篇28.571%
08.History, 20th Century2 篇28.571%
09.Molecular Biology2 篇28.571%
10.Polymerase Chain Reaction2 篇28.571%




https://blog.sciencenet.cn/blog-280034-1356770.html

上一篇:诺奖发现 神经退行性疾病
下一篇:诺奖发现 乳腺癌 BRCA1基因突变
收藏 IP: 223.72.71.*| 热度|

2 杨学祥 范振英

该博文允许注册用户评论 请点击登录 评论 (0 个评论)

数据加载中...

Archiver|手机版|科学网 ( 京ICP备07017567号-12 )

GMT+8, 2022-11-27 03:18

Powered by ScienceNet.cn

Copyright © 2007- 中国科学报社

返回顶部