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诺奖发现 神经退行性疾病

已有 737 次阅读 2022-9-25 14:40 |个人分类:诺贝尔奖|系统分类:论文交流



长谷川成人,日本东京都医学科学研究所脑神经科学部主任

Virginia Man-Yee Lee,美国宾夕法尼亚大学病理学和实验医学系阿尔茨海默病研究John H. Ware 3rd 讲席教授、神经退行性疾病研究中心主任

获奖原因:发现TDP-43以及对神经退行性疾病研究的其他贡献。TDP-43是肌萎缩性脊髓侧索硬化症(ALS)和额颞叶变性(FTLD)的病理特征。

https://news.sciencenet.cn/htmlnews/2022/9/486641.shtm

https://pubmed.ncbi.nlm.nih.gov/17095949/



Review

 

Ann Pharm Fr

2006 Sep;64(5):291-307.

 doi: 10.1016/s0003-4509(06)75322-6.

[A Nematode Nobel Prize: Caenorhabditis elegans]

[Article in French]

J Savel 1F Clostre

Affiliations expand

Abstract

The Nematode Caenorhabditis elegans (C. elegans) is an established model increasingly used for studying human disease pathogenesis. C. elegans models are based on the mutagenesis of human disease genes conserved in this Nematode or on the transgenesis with disease genes not conserved in C. elegans. Genetic examinations will give new insights on the cellular and molecular mechanisms that are altered in some neurodegenerative diseases like Duchenne's muscular dystrophy, Huntington's disease and Alzheimer's disease. C. elegans may be used for primary screening of new compounds that may be used as drugs in these diseases.

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Publication types

  • English Abstract

  • Review

MeSH terms

  • Alzheimer Disease / genetics

  • Alzheimer Disease / physiopathology

  • Animals

  • Bacterial Infections / physiopathology

  • Caenorhabditis elegans / genetics

  • Caenorhabditis elegans / microbiology

  • Caenorhabditis elegans / physiology*

  • Disease Models, Animal

  • Gametogenesis

  • Humans

  • Huntington Disease / genetics

  • Huntington Disease / physiopathology

  • Muscular Dystrophy, Duchenne / genetics

  • Muscular Dystrophy, Duchenne / physiopathology

  • Neurobiology

  • Nobel Prize

  • Reproduction

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