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诺奖文集 1998年诺贝尔医学奖 佛契哥特 美国药理学家

已有 390 次阅读 2022-9-9 06:37 |个人分类:诺贝尔奖|系统分类:论文交流

罗伯特·佛契哥特(Robert F. Furchgott,1916年6月4日-2009年5月18日),出生于南卡罗来纳州,美国教授、药理学家。

因和费瑞·慕拉德、路伊格纳洛三人发现氧化氮是一种可以传递信息的气体,而荣获1998年诺贝尔医学奖

https://baike.baidu.com/item/%E7%BD%97%E4%BC%AF%E7%89%B9%C2%B7%E4%BD%9B%E5%A5%91%E5%93%A5%E7%89%B9/8664984?fromModule=lemma_inlink&fromtitle=%E7%BD%97%E4%BC%AF%C2%B7%E4%BD%9B%E5%A5%91%E5%93%A5%E7%89%B9&fromid=9556486

https://pubmed.ncbi.nlm.nih.gov/34182659/


summary-FurchgottR-set.txt

http://www.pubmedplus.cn/P/SearchQuickResult?wd=b079d93e-10c0-420c-b3cf-93c4187872fb


Review

 

Angew Chem Int Ed Engl

1999 Jul 12;38(13-14):1870-1880.

 doi: 10.1002/(SICI)1521-3773(19990712)38:13/14<1870::AID-ANIE1870>3.0.CO;2-8.

Endothelium-Derived Relaxing Factor: Discovery, Early Studies, and Identifcation as Nitric Oxide (Nobel Lecture)

Robert F Furchgott 1

Affiliations expand

Abstract

The presence of air bubbles, and thus the unintentional removal of endothelial cells, may have prevented the discovery of endothelium-dependent vasodilation at an earlier date. In investigations with perfused rabbit central ear artery the infusion of acetylcholine, a known potent prejunctional inhibitor of adrenergic neurotransmission, did not inhibit vasoconstriction produced by infused norepinephrine. It was later determined that air bubbles in the perfusion line had mechanically removed the endothelial cells, and as a result no release of endothelium-derived relaxing factor (EDRF) could take place.

Keywords: Enzymes; Neurotransmitters; Nitric oxide; Nobel lecture; Signal transduction.

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