本研究组工作领域20强发表物出炉

我们实验室有2项在1位和9位，其中第11位的工作更有意义（我觉的！）我们也开创性地在神州大地发现了有关病例，如果可能，我们将会改写这个故事。

 

这个领域的研究被称为“21世纪对分子生物学家的挑战”，进展相当困难！

1. The roles of SbcCD and RNaseE in the transcription of GAA x TTC repeats in Escherichia coli.
Pan X, Ding Y, Shi L:
DNA Repair (Amst); 2009 Nov 2;8(11):1321-7

2. Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia.
Kim E, Napierala M, Dent SY:
Nucleic Acids Res; 2011 Oct;39(19):8366-77

3. Transposon Tn7 preferentially inserts into GAA*TTC triplet repeats under conditions conducive to Y*R*Y triplex formation.
Mancuso M, Sammarco MC, Grabczyk E:
PLoS One; 2010;5(6):e11121

4. Friedreich's ataxia (GAA)n•(TTC)n repeats strongly stimulate mitotic crossovers in Saccharomyces cerevisae.
Tang W, Dominska M, Greenwell PW, Harvanek Z, Lobachev KS, Kim HM, Narayanan V, Mirkin SM, Petes TD:
PLoS Genet; 2011;7(1):e1001270

5. Long intronic GAA repeats causing Friedreich ataxia impede transcription elongation.
Punga T, Bühler M:
EMBO Mol Med; 2010 Apr;2(4):120-9

6. Structure-specific recognition of Friedreich's ataxia (GAA)n repeats by benzoquinoquinoxaline derivatives.
Bergquist H, Nikravesh A, Fernández RD, Larsson V, Nguyen CH, Good L, Zain R:
Chembiochem; 2009 Nov 2;10(16):2629-37

7. Absence of aprataxin gene mutations in a Greek cohort with sporadic early onset ataxia and normal GAA triplets in frataxin gene.
Daiou C, Christodoulou K, Xiromerisiou G, Panas M, Dardiotis E, Kladi A, Speletas M, Ntaios G, Papadimitriou A, Germenis A, Hadjigeorgiou GM:
Neurol Sci; 2010 Jun;31(3):393-7

8. Detection of interruptions in the GAA trinucleotide repeat expansion in the FXN gene of Friedreich ataxia.
Holloway TP, Rowley SM, Delatycki MB, Sarsero JP:
Biotechniques; 2011 Mar;50(3):182-6

9. Transcription of AAT•ATT triplet repeats in Escherichia coli is silenced by H-NS and IS1E transposition.
Pan X, Liao Y, Liu Y, Chang P, Liao L, Yang L, Li H:
PLoS One; 2010;5(12):e14271

10. Two pathways for RNase E action in Escherichia coli in vivo and bypass of its essentiality in mutants defective for Rho-dependent transcription termination.
Anupama K, Leela JK, Gowrishankar J:
Mol Microbiol; 2011 Dec;82(6):1330-48

11. North and South Indian populations share a common ancestral origin of Friedreich's ataxia but vary in age of GAA repeat expansion.
Singh I, Faruq M, Mukherjee O, Jain S, Pal PK, Srivastav MV, Behari M, Srivastava AK, Mukerji M:
Ann Hum Genet; 2010 May;74(3):202-10

12. Rho-dependent termination of ssrS (6S RNA) transcription in Escherichia coli: implication for 3' processing of 6S RNA and expression of downstream ygfA (putative 5-formyl-tetrahydrofolate cyclo-ligase).
Chae H, Han K, Kim KS, Park H, Lee J, Lee Y:
J Biol Chem; 2011 Jan 7;286(1):114-22

13. Roles for the transcription elongation factor NusA in both DNA repair and damage tolerance pathways in Escherichia coli.
Cohen SE, Lewis CA, Mooney RA, Kohanski MA, Collins JJ, Landick R, Walker GC:
Proc Natl Acad Sci U S A; 2010 Aug 31;107(35):15517-22

14. Transcription-coupled nucleotide excision repair of a gene transcribed by bacteriophage T7 RNA polymerase in Escherichia coli.
Ganesan AK, Hanawalt PC:
DNA Repair (Amst); 2010 Sep 4;9(9):958-63

15. The SMC-like protein complex SbcCD enhances DNA polymerase IV-dependent spontaneous mutation in Escherichia coli.
Storvik KA, Foster PL:
J Bacteriol; 2011 Feb;193(3):660-9

16. Transcription regulation of the Escherichia coli pcnB gene coding for poly(A) polymerase I: roles of ppGpp, DksA and sigma factors.
Nadratowska-Wesołowska B, Słomińska-Wojewódzka M, Łyzeń R, Wegrzyn A, Szalewska-Pałasz A, Wegrzyn G:
Mol Genet Genomics; 2010 Oct;284(4):289-305

17. Expansion of a chromosomal repeat in Escherichia coli: roles of replication, repair, and recombination functions.
Poteete AR:
BMC Mol Biol; 2009;10:14

18. High-temperature protein G is essential for activity of the Escherichia coli clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system.
Yosef I, Goren MG, Kiro R, Edgar R, Qimron U:
Proc Natl Acad Sci U S A; 2011 Dec 13;108(50):20136-41

19. Transcription analysis of central metabolism genes in Escherichia coli. Possible roles of sigma38 in their expression, as a response to carbon limitation.
Olvera L, Mendoza-Vargas A, Flores N, Olvera M, Sigala JC, Gosset G, Morett E, Bolívar F:
PLoS One; 2009;4(10):e7466

20. Single amino acid changes in the predicted RNase H domain of Escherichia coli RNase G lead to complementation of RNase E deletion mutants.
Chung DH, Min Z, Wang BC, Kushner SR:
RNA; 2010 Jul;16(7):1371-85