TOP25热点论文（药理学、药学及毒理学）

诸平

将2014年10月至12月《今日药物发现》（Drug Discovery Today）杂志发表的药理学、药学及毒理学TOP25热点论文摘引如下，供大家参考。

	Pharmacology, Toxicology and Pharmaceutical Science Drug Discovery Today October to December 2014

1. The growing impact of click chemistry on drug discovery• Review article
   Drug Discovery Today, Volume 8, Issue 24, December 2003, Pages 1128-1137
   Kolb, H.C.; Sharpless, K.B.
   

2. Natural products in drug discovery• Review article
   Drug Discovery Today, Volume 13, Issue 19-20, October 2008, Pages 894-901
   Harvey, A.L.
   

3. Hydrogels: from controlled release to pH-responsive drug delivery• Review article
   Drug Discovery Today, Volume 7, Issue 10, May 2002, Pages 569-579
   Gupta, P.; Vermani, K.; Garg, S.
   

4. Designing novel building blocks is an overlooked strategy to improve compound quality• Review article
   Drug Discovery Today, Volume 20, Issue 1, January 2015, Pages 11-17
   Goldberg, F.W.; Kettle, J.G.; Kogej, T.; Perry, M.W.D.; Tomkinson, N.P.
   

5. Cancer nanotechnology: application of nanotechnology in cancer therapy• Review article
   Drug Discovery Today, Volume 15, Issue 19-20, October 2010, Pages 842-850
   Misra, R.; Acharya, S.; Sahoo, S.K.
   

6. PEGylation, successful approach to drug delivery• Review article
   Drug Discovery Today, Volume 10, Issue 21, November 2005, Pages 1451-1458
   Veronese, F.M.; Pasut, G.
   

7. Dendrimers and dendritic polymers in drug delivery• Review article
   Drug Discovery Today, Volume 10, Issue 1, January 2005, Pages 35-43
   Gillies, E.R.; Frechet, J.M.J.
   

8. Stabilization of protein-protein interactions by small molecules• Review article
   Drug Discovery Today, Volume 19, Issue 11, November 2014, Pages 1812-1821
   Giordanetto, F.; Schafer, A.; Ottmann, C.
   

9. Multi-target approach for natural products in inflammation• Review article
   Drug Discovery Today, Volume 19, Issue 12, December 2014, Pages 1871-1882
   Koeberle, A.; Werz, O.
   

10. Delivering a disease-modifying treatment for Huntington's disease• Review article
    Drug Discovery Today, Volume 20, Issue 1, January 2015, Pages 50-64
    Godinho, B.M.D.C.; Malhotra, M.; O'Driscoll, C.M.; Cryan, J.F.
    

11. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications• Review article
    Drug Discovery Today, Volume 6, Issue 8, April 2001, Pages 427-436
    Esfand, R.; Tomalia, D.A.
    

12. Is nanotechnology a boon for oral drug delivery?• Review article
    Drug Discovery Today, Volume 19, Issue 10, October 2014, Pages 1530-1546
    Agrawal, U.; Sharma, R.; Gupta, M.; Vyas, S.P.
    

13. Antibody-drug conjugates: current status and future directions• Review article
    Drug Discovery Today, Volume 19, Issue 7, July 2014, Pages 869-881
    Perez, H.L.; Cardarelli, P.M.; Deshpande, S.; Gangwar, S.; Schroeder, G.M.; Vite, G.D.; Borzilleri, R.M.
    

14. Chemical approaches to targeting drug resistance in cancer stem cells• Review article
    Drug Discovery Today, Volume 19, Issue 10, October 2014, Pages 1547-1562
    Sotiropoulou, P.A.; Christodoulou, M.S.; Silvani, A.; Herold-Mende, C.; Passarella, D.
    

15. Therapeutic applications of the cell-penetrating HIV-1 Tat peptide• Review article
    Drug Discovery Today, Volume 20, Issue 1, January 2015, Pages 76-85
    Rizzuti, M.; Nizzardo, M.; Zanetta, C.; Ramirez, A.; Corti, S.
    

16. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs• Review article
    Drug Discovery Today, Volume 12, Issue 23-24, December 2007, Pages 1068-1075
    Vasconcelos, T.; Sarmento, B.; Costa, P.
    

17. Back-up strategies in drug discovery: what, how and when?• Review article
    Drug Discovery Today, Volume 19, Issue 11, November 2014, Pages 1808-1811
    Provins, L.; Jnoff, E.; Genicot, C.
    

18. Synthetic therapeutic peptides: science and market• Review article
    Drug Discovery Today, Volume 15, Issue 1-2, January 2010, Pages 40-56
    Vlieghe, P.; Lisowski, V.; Martinez, J.; Khrestchatisky, M.
    

19. Evolutions in fragment-based drug design: the deconstruction-reconstruction approach• Review article
    Drug Discovery Today, Volume 20, Issue 1, January 2015, Pages 105-113
    Chen, H.; Zhou, X.; Wang, A.; Zheng, Y.; Gao, Y.; Zhou, J.
    

20. Nanotech approaches to drug delivery and imaging• Review article
    Drug Discovery Today, Volume 8, Issue 24, December 2003, Pages 1112-1120
    Sahoo, S.K.; Labhasetwar, V.
    

21. Big data in biomedicine• Review article
    Drug Discovery Today, Volume 19, Issue 4, April 2014, Pages 433-440
    Costa, F.F.
    

22. Towards a sustainable system of drug development• Review article
    Drug Discovery Today, Volume 19, Issue 11, November 2014, Pages 1711-1720
    Moors, E.H.M.; Cohen, A.F.; Schellekens, H.
    

23. Academic drug discovery centres: the economic and organisational sustainability of an emerging model• Review article
    Drug Discovery Today, Volume 19, Issue 11, November 2014, Pages 1699-1710
    Schultz Kirkegaard, H.; Valentin, F.
    

24. Cell-penetrating peptides: classes, origin, and current landscape• Review article
    Drug Discovery Today, Volume 17, Issue 15-16, August 2012, Pages 850-860
    Milletti, F.
    

25. Drug discovery in pharmaceutical industry: productivity challenges and trends• Review article
    Drug Discovery Today, Volume 17, Issue 19-20, October 2012, Pages 1088-1102
    Khanna, I.