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卡罗林斯卡学院的诺贝尔大会决定将 2021 年诺贝尔生理学或医学奖授予大卫·朱利叶斯（David Julius）和阿徳姆·帕塔波蒂安（Ardem Patapoutian），因为他们“发现了温度和触觉的感受器”。通过解释感知热、冷和机械力的分子基础解开了大自然的秘密之一，这是我们感受、解释和与内部和外部环境互动能力的基础。
1 大卫·朱利叶斯（David Julius），1955年11月4日生于美国纽约。获奖时所属单位为美国加州大学旧金山分校（University of California, San Francisco）。其获奖原因是“因为发现了温度和触觉的感受器。”与阿徳姆·帕塔波蒂安（Ardem Patapoutian）二人平均分享 2021 年诺贝尔生理学或医学奖。
Dimensions数据库统计结果
高引论文（被引频次≥1000次）
Title, Author(s), Bibliographic reference -
About the metrics
Michael J. Caterina, Mark A. Schumacher, Makoto Tominaga, Tobias A. Rosen, Jon D. Levine, David Julius
1997, Nature - Article
Capsaicin, the main pungent ingredient in ‘hot’ chilli peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the centr...more
Makoto Tominaga, Michael J Caterina, Annika B Malmberg, Tobias A Rosen, Heather Gilbert, Kate Skinner, Brigitte E Raumann, Allan I Basbaum, David Julius
1998, Neuron - Article
Capsaicin, the main pungent ingredient in "hot" chili peppers, elicits buming pain by activating specific (vanilloid) receptors on sensory nerve endings. The cloned vanilloid receptor (VR1) ...more
Allan I. Basbaum, Diana M. Bautista, Grégory Scherrer, David Julius
2009, Cell - Article
The nervous system detects and interprets a wide range of thermal and mechanical stimuli, as well as environmental and endogenous chemical irritants. When intense, these stimuli generate acute pain, a...more
David D. McKemy, Werner M. Neuhausser, David Julius
2002, Nature - Article
The cellular and molecular mechanisms that enable us to sense cold are not well understood. Insights into this process have come from the use of pharmacological agents, such as menthol, that elicit a ...more
David Julius, Allan I. Basbaum
2001, Nature - Article
The sensation of pain alerts us to real or impending injury and triggers appropriate protective responses. Unfortunately, pain often outlives its usefulness as a warning system and instead becomes chr...more
Peter M. Zygmunt, Jesper Petersson, David A. Andersson, Huai-hu Chuang, Morten Sørgård, Vincenzo Di Marzo, David Julius, Edward D. Högestätt
1999, Nature - Article
The endogenous cannabinoid receptor agonist anandamide1 is a powerful vasodilator of isolated vascular preparations2,3,4, but its mechanism of action is unclear. Here we show that the vasodilator resp...more
Sven-Eric Jordt, Diana M. Bautista, Huai-hu Chuang, David D. McKemy, Peter M. Zygmunt, Edward D. Högestätt, Ian D. Meng, David Julius
2004, Nature - Article
Wasabi, horseradish and mustard owe their pungency to isothiocyanate compounds. Topical application of mustard oil (allyl isothiocyanate) to the skin activates underlying sensory nerve endings, thereb...more
Diana M. Bautista, Sven-Eric Jordt, Tetsuro Nikai, Pamela R. Tsuruda, Andrew J. Read, Jeannie Poblete, Ebenezer N. Yamoah, Allan I. Basbaum, David Julius
2006, Cell - Article
TRPA1 is an excitatory ion channel targeted by pungent irritants from mustard and garlic. TRPA1 has been proposed to function in diverse sensory processes, including thermal (cold) nociception, hearin...more
Michael J Caterina, David Julius
2001, Annual Review of Neuroscience - Article
The detection of painful stimuli occurs primarily at the peripheral terminals of specialized sensory neurons called nociceptors. These small-diameter neurons transduce signals of a chemical, mechanica...more
Michael J. Caterina, Tobias A. Rosen, Makoto Tominaga, Anthony J. Brake, David Julius
1999, Nature - Article
Pain-producing heat is detected by several classes of nociceptive sensory neuron that differ in their thermal response thresholds1,2,3. The cloned capsaicin receptor, also known as the vanilloid recep...more
Gunther Hollopeter, Hans-Michael Jantzen, Diana Vincent, Georgia Li, Laura England, Vanitha Ramakrishnan, Ruey-Bing Yang, Paquita Nurden, Alan Nurden, David Julius, Pamela B. Conley
2001, Nature - Article
Platelets have a crucial role in the maintenance of normal haemostasis, and perturbations of this system can lead to pathological thrombus formation and vascular occlusion, resulting in stroke, myocar...more
Maofu Liao, Erhu Cao, David Julius, Yifan Cheng
2013, Nature - Article
Transient receptor potential (TRP) channels are sensors for a wide range of cellular and environmental signals, but elucidating how these channels respond to physical and chemical stimuli has been ham...more
Laurence H. Tecott, Linda M. Sun, Susan F. Akana, Alison M. Strack, Daniel H. Lowenstein, Mary F. Dallman, David Julius
1995, Nature - Article
SEROTONIN (5-hydroxytryptamine, 5-HT) is a monoaminergic neurotransmitter that is believed to modulate numerous sensory, motor and behavioural processes in the mammalian nervous system1-3. These diver...more
Huai-hu Chuang, Elizabeth D. Prescott, Haeyoung Kong, Shannon Shields, Sven-Eric Jordt, Allan I. Basbaum, Moses V. Chao, David Julius
2001, Nature - Article
Tissue injury generates endogenous factors that heighten our sense of pain by increasing the response of sensory nerve endings to noxious stimuli1,2. Bradykinin and nerve growth factor (NGF) are two s...more
2 阿徳姆·帕塔波蒂安（Ardem Patapoutian），1967年出生于黎巴嫩贝鲁特（Beirut, Lebanon）。获奖时所属机构为美国加州拉霍亚市斯克里普斯研究所霍华德休斯医学研究所（Howard Hughes Medical Institute, Scripps Research, La Jolla, CA, USA）。其获奖原因是“发现了温度和触觉的感受器。”与大卫·朱利叶斯（David Julius）二人平均分享 2021 年诺贝尔生理学或医学奖。
Dimensions数据库统计结果
高引论文（被引频次≥1000次）
Title, Author(s), Bibliographic reference -
About the metrics
Gina M. Story, Andrea M. Peier, Alison J. Reeve, Samer R. Eid, Johannes Mosbacher, Todd R. Hricik, Taryn J. Earley, Anne C. Hergarden, David A. Andersson, Sun Wook Hwang, Peter McIntyre, Tim Jegla, Stuart Bevan, Ardem Patapoutian
2003, Cell - Article
Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The com...more
Andrea M. Peier, Aziz Moqrich, Anne C. Hergarden, Alison J. Reeve, David A. Andersson, Gina M. Story, Taryn J. Earley, Ilaria Dragoni, Peter McIntyre, Stuart Bevan, Ardem Patapoutian
2002, Cell - Article
A distinct subset of sensory neurons are thought to directly sense changes in thermal energy through their termini in the skin. Very little is known about the molecules that mediate thermoreception by...more
Michael Bandell, Gina M Story, Sun Wook Hwang, Veena Viswanath, Samer R Eid, Matt J Petrus, Taryn J Earley, Ardem Patapoutian
2004, Neuron - Article
Six members of the mammalian transient receptor potential (TRP) ion channels respond to varied temperature thresholds. The natural compounds capsaicin and menthol activate noxious heat-sensitive TRPV1...more
Andrew I. Su, Michael P. Cooke, Keith A. Ching, Yaron Hakak, John R. Walker, Tim Wiltshire, Anthony P. Orth, Raquel G. Vega, Lisa M. Sapinoso, Aziz Moqrich, Ardem Patapoutian, Garret M. Hampton, Peter G. Schultz, John B. Hogenesch
2002, Proceedings of the National Academy of Sciences of the United States of America - Article
High-throughput gene expression profiling has become an important tool for investigating transcriptional activity in a variety of biological samples. To date, the vast majority of these experiments ha...more
Bertrand Coste, Jayanti Mathur, Manuela Schmidt, Taryn J. Earley, Sanjeev Ranade, Matt J. Petrus, Adrienne E. Dubin, Ardem Patapoutian
2010, Science - Article
Mechanical stimuli drive many physiological processes, including touch and pain sensation, hearing, and blood pressure regulation. Mechanically activated (MA) cation channel activities have been recor...more
更多信息可以观看由诺贝尔大会和诺贝尔委员会秘书长托马斯·珀尔曼 (Thomas Perlmann) 颁发的 2021 年诺贝尔生理学或医学奖宣布的相关音像材料，以及新闻稿：2021年诺贝尔生理学或医学奖和深度报道。
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