http://en.wikipedia.org/wiki/C-Jun_N-terminal_kinases
http://baike.baidu.com/view/2211480.htm
丝氨酸苏氨酸激酶c-Jun N-terminal kinases (JNKs)属于MAPK家族,磷酸化c-Jun 的 Ser-63 and Ser-73,上游被MKK4 and MKK7 激活,包括三个亚型 JNK1 (four isoforms), JNK2 (four isoforms) and JNK3 (two isoforms).
JNK1:Mitogen-activated protein kinase 8
UniProtKB/Swiss-Prot ID :P45983
Alternative name:JNK-46,Stress-activated protein kinase JNK1,c-Jun N-terminal kinase 1
aa:1-427
Binding site :ATP-binding(26-321),Nucleotide-binding(32-40)
PDB ID:
Entry Method Resolution (Å) Chain Positions
1UKH X-ray 2.35 A 1-363
1UKI X-ray 2.70 A 1-363
2G01 X-ray 3.50 A/B 1-364
2GMX X-ray 3.50 A/B 1-364
2H96 X-ray 3.00 A/B 1-364
2NO3 X-ray 3.20 A/B 1-364
3ELJ X-ray 1.80 A 1-364
3O17 X-ray 3.00 A/B 1-364
3O2M X-ray 2.70 A/B 1-364
JNK2:Mitogen-activated protein kinase 9
UniProtKB/Swiss-Prot ID :P45984
aa:1-424
Binding site :ATP-binding(26-321),Nucleotide-binding(32-40)
PDB ID:
Entry Method Resolution (Å) Chain Positions
3E7O X-ray 2.14 A/B 7-362
3NPC X-ray 2.35 A/B 7-364
JNK3:Mitogen-activated protein kinase 10
UniProtKB/Swiss-Prot ID :P53779
aa:1-464
Binding site :ATP-binding(64-359),Nucleotide-binding(70-78)
PDB ID:
Entry Method Resolution(Å) Chain Positions
1JNK X-ray 2.30 A 1-423
1PMN X-ray 2.20 A 40-401
1PMQ X-ray 2.20 A 40-401
1PMU X-ray 2.70 A 40-401
1PMV X-ray 2.50 A 40-401
2B1P X-ray 1.90 A 46-400
2EXC X-ray 2.75 X 45-400
2O0U X-ray 2.10 A 39-402
2O2U X-ray 2.45 A 39-402
2OK1 X-ray 2.40 A 40-402
2P33 X-ray 2.40 A 40-402
2R9S X-ray 2.40 A/B 46-401
2WAJ X-ray 2.40 A 39-402
2ZDT X-ray 2.00 A 39-402
2ZDU X-ray 2.50 A 39-402
3CGF X-ray 3.00 A 40-402
3CGO X-ray 3.00 A 40-402
3DA6 X-ray 2.00 A 39-402
3FI2 X-ray 2.28 A 39-402
3FI3 X-ray 2.20 A 39-402
3FV8 X-ray 2.28 A 39-402
3G90 X-ray 2.40 X 40-402
3G9L X-ray 2.20 X 40-402
3G9N X-ray 2.80 A 40-402
3KVX X-ray 2.40 A 39-402
3OXI X-ray 2.20 A 40-401
3PTG X-ray 2.43 A 40-401
https://blog.sciencenet.cn/blog-209737-473360.html
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