After decades of research and development related to slow until the 1980s, CTSB, CTSH, CTSL was only identified and sequenced. 1990, CTSB determined the crystal structureof the human being, since studies on cathepsin rapid development, rapidprogress. Hydrolysis of the polypeptide according to the method can be divided intoexopeptidases endopeptidase enzyme, wherein the enzyme but also according tothe outer end of the peptide when the peptide bond hydrolysis is divided intodifferent origin aminopeptidase and carboxypeptidase; protease activity accordingto the groups of different catalytic properties of the center, which can bedivided into E-64 serineproteases (serine protease), threonine protease (threonine protease), cysteine protease (cysteine protease),aspartic proteases (aspartic protease) and metalloprotease (metalloprotease)and the like; protease according to the optimal reaction pH values, can be divided into the acid protease, neutralprotease and alkaline protease. Many proteases, cysteine proteases are more relevant research, which is widelypresent in the organism, such as bacteria, viruses, plants, lower and higheranimals, including parasites, variety. This class contains a protease activesite cysteine residue essential and depends on itcatalyzes the hydrolysis of peptide bonds mercapto group, it is also referredto as thiol proteases (thiol protease).