笹井芳树生平重量级学术成果

喻海良，2014-08-05

笹井芳树今天被证实自杀身亡，真是很可惜的。应该说，他是细胞研究领域的国际重量级人物。笹井芳树一共发表100多篇学术论文，被引用12000次以上，其H因子为42以上。其中被引用超过300次以上的论文有12篇，100次以上有33篇。

笹井出生于兵库县，1986年自京都大学医学系毕业，1998年36岁的他成为了京都大学再生医科学研究所教授。笹井是获得2012年诺贝尔奖的英国科学家约翰·格登博士的再传弟子。他从胚胎干细胞（ES细胞）制作出的立体的大脑及眼部组织引起了巨大反响。2013年度笹井被选为使用ES细胞、诱导多能干细胞（iPS细胞）治疗眼部疾病的国家级项目负责人，积极推动了研究成果的医疗应用。

下面列举下发表过的一些重要学术成果：

·         Inomata, H., Shibata, T., Haraguchi, T., Sasai, Y.XScaling of dorsal-ventral patterning by embryo size-dependent degradation of spemann's organizer signals. 2013. Cell. 153 (6), pp. X1296-1311.

·         Inomata, H., Haraguchi, T., Sasai, Y.Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation. 2008. Cell. 134 (5), pp. 854-865.

·         Sasai, N., Yakura, R., Kamiya, D., Nakazawa, Y., Sasai, Y.Ectodermal Factor Restricts Mesoderm Differentiation by Inhibiting p53. 2008. Cell. 133 (5), pp. 878-890

·         Piccolo, S., Sasai, Y., Lu, B., De Robertis, E.M.Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4. 1996. Cell. 86 (4), pp. 589-598

·         Holley, S.A., Neul, J.L., Attisano, L., (...), De Robertis, E.M., Ferguson, E.L.The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor. 1996. Cell. 86 (4), pp. 607-617

·         Sasai, Y., Lu, B., Steinbeisser, H., (...), Gont, L.K., De Robertis, E.M.Xenopus chordin: A novel dorsalizing factor activated by organizer- specific homeobox genes. 1994. Cell. 79 (5), pp. 779-790

·         Sasai, Y.Cytosystems dynamics in self-organization of tissue architecture. 2013. Nature. 493 (7432), pp. 318-326

 

·         Suga, H., Kadoshima, T., Minaguchi, M., (...), Oiso, Y., Sasai, Y.Self-formation of functional adenohypophysis in three-dimensional culture. 2011. Nature. 480 (7375), pp. 57-62

·         Eiraku, M., Takata, N., Ishibashi, H., (...), Adachi, T., Sasai, Y.Self-organizing optic-cup morphogenesis in three-dimensional culture. 2011. Nature. 472 (7341), pp. 51-58

·         Kamiya, D., Banno, S., Sasai, N., (...), Nishikawa, S.-I., Sasai, Y.Intrinsic transition of embryonic stem-cell differentiation into neural progenitors. 2011. Nature. 470 (7335), pp. 503-510

·         Sasai, Y.Developmental biology: A blank canvas no more. 2005. Nature. 435 (7041), pp. 433-434

·         Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., De Robertis, E.M.Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. 1996. Nature. 382 (6592), pp. 595-601

·         De Robertis, E.M., Sasai, Y.A common plan for dorsoventral patterning in Bilateria. 1996. Nature. 380 (6569), pp. 37-40

·         Holley, S.A., Jackson, P.D., Sasai, Y., (...), Hoffmann, F.M., Ferguson, E.L.A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin. 1995. Nature. 376 (6537), pp. 249-253

·         Sasai, Y., Lu, B., Steinbeisser, H., De Robertis, E.M.Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. 1995. Nature. 376 (6538), pp. 333-336

·         Kawasaki, H., Mizuseki, K., Nishikawa, S., (...), Nishikawa, S.-I., Sasai, Y.Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. 2000. Neuron. 28 (1), pp. 31-40

    逝者为大，以上论文不包含2014年被要求撤稿的两篇论文。

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