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2017年BJU International全球奖

已有 913 次阅读 2017-3-6 16:03 |个人分类:Health Science|系统分类:博客资讯

       热烈祝贺复旦大学附属中山医院的刘立大夫获得英国泌尿外科医师协会官方期刊BJU International的2017年全球奖(BJUI Global Prize 2017)。下图为刘立大夫与BJUI主编Prokar Dasgupt教授在澳大利亚与新西兰泌尿学会年会上合影。

       刘立大夫以第一作者的身份(通讯作者为复旦大学中山医学院泌尿外科的郭剑明教授)在BJUI上发表了题为:Enhancer of zeste homolog 2 (EZH2) promotes tumour cell migration and invasion via epigenetic repression of E-cadherin in renal cell carcinoma的文章,目前这篇文章免费开放给所有感兴趣的读者阅读。


文章摘要:

Objective
To investigate the molecular mechanism and clinical significance for an oncogenic role of enhancer of zeste homolog 2 (EZH2) in renal cell carcinoma (RCC).

Materials and Methods
Immunohistochemistry analyses of EZH2, histone H3 trimethyl Lys27 (H3K27me3) and E-cadherin were performed in tumour tissue samples from 257 patients with RCC. Regulatory effects of EZH2 on E-cadherin expression were examined by quantitative real-time polymerase chain reaction, Western blot, chromatin immunoprecipitation assay and immunohistochemical staining. Migration and invasion assays were performed in RCC cell lines. Tumour xenograft experiments with RCC cells were carried out in nude mice.

Results
EZH2 promoted migration and invasion in RCC cell lines. Silencing EZH2 with short-hairpin EZH2 (shEZH2) or 3-deazaneplanocin A (DZNep) inhibited migration and invasion (P < 0.001), up-regulated the expression of E-cadherin in vitro, inhibited tumour growth, and prolonged survival in vivo (P = 0.022). EZH2 expression accompanied with E-cadherin repression was associated with advanced disease stage (P = 0.004) and poor overall (P < 0.001) and disease-free survival (P < 0.001).

Conclusion
EZH2 may contribute to RCC progression and is a potential therapeutic target for advanced RCC.


关于BJU International

BJUI是英国泌尿外科医师协会官方期刊,是泌尿学领域备受尊敬的顶尖期刊之一,目前由Wiley出版。旨在为泌尿学领域的研究者提供高水准的研究及临床信息,引发广大学者对泌尿学领域最新最先进案例的关注。本刊发表成年人及儿童泌尿学方面的原创性研究论文、综述、评论和教育类文章,尤其注重这些研究的临床相关性。研究范围涵盖泌尿学各个方向,主要包括泌尿肿瘤学、机器人和腹腔镜检查、上泌尿道疾病、功能泌尿学、性医学、儿科学、转换医学、外科教育等。



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