Lancet Neurol——血液NfL水平是亨廷顿病的预后标志物

Lancet Neurol—血液NfL水平是亨廷顿病的预后标志物

1.Associations between NfL concentrations in plasma and disease stage, age, and CAG triplet repeat count

2.Associations between NfL concentrations in plasma at baseline and cross-sectional measures of cognitive function, motor impairment, and brain volume on MRI

3.Association between baseline NfL concentration in plasma and progression to manifest Huntington’s disease in HTT mutation carriers who were premanifest at baseline

4.Associations between baseline NfL concentration in plasma and longitudinal change in cognitive,motor, and functional decline and brain atrophy

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