Long non-coding RNA CCAT1/miR-148a axis promotes osteosarcoma proliferation and migration through regulating PIK3IP1

Jingwei Zhao and Liming Cheng

Department of Orthopaedics, Tongji Hospital, School of Medicine Tongji University, Shanghai 200065, China

Acta Biochim Biophys Sin 2017, 49: 503–512; doi: 10.1093/abbs/gmx041

Osteosarcoma is the most frequent type of malignant primary bone tumor. Although many efforts have been made, the survival rate of osteosarcoma still remains unsatisfied. Long non-coding RNAs (lncRNAs) have been demonstrated to be associated with many diseases including tumors, and involved in the regulation of a wide array of pathophysiological processes. Colon-cancer-associated transcript-1 (CCAT1) was first identified in colon cancer and has subsequently been reported to perform many functions in tumor progression. The present study aimed to comprehensively explore the biological functions of CCAT1 and its underlying mechanism in osteosarcoma cells. Our findings revealed that CCAT1 was upregulated in osteosarcoma tissues and cells, and was involved in the proliferation and migration of osteosarcoma via regulating miR-148a/phosphatidyl inositol 3-kinase interacting protein 1 (PIK3IP1) signal pathway.

High level of CCAT1 regulates osteosarcoma cell proliferation and migration/invasion

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