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Mini-Review:Role of BDNF in the taste system

已有 1341 次阅读 2014-12-12 16:29 |个人分类:生物前沿|系统分类:论文交流

Mini-Review

Role of BDNF in the taste system

Lingbin Meng , Xiaolei Chen , Rongqiang Yang & Rui Ji

Abstract  

Neurotrophins are a family of proteins that regulateneural survival, development, function and plasticity in the central and theperipheral nervous system. There are four neurotrophins: NGF, BDNF, NT-3 andNT-4. Among them, BDNF is mostly studied in the taste system due to its highexpression. Recent studies have shown BDNF play an important role in thedevelopmental and mature taste system, by regulating survival of taste cellsand geniculate ganglion neurons, and maintaining and guiding taste nerveinnervations. These studies imply BDNF has great potentialities for therapeuticusage to enhance sensory regeneration following nerve injury, with aging, andin some neurodegenerative diseases.


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