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氢气生理盐水对紫外线B皮肤损伤的保护作用

已有 3696 次阅读 2013-4-6 07:23 |个人分类:氢气生理盐水|系统分类:科研笔记|关键词:紫外线,皮肤| 皮肤, 紫外线

氢气生理盐水对紫外线B皮肤损伤的保护作用

南京医科大学第一附属医院皮肤科最近的研究发现,氢气可以对抗紫外线引起的皮肤损伤,文章发表在J Biomed Res.(原南京医科大学学报)上。

众所周知,太阳来源的紫外线可以引起皮肤损伤,其中紫外线BUVB)辐射诱导皮肤产生的活性氧(ROS)是导致损伤的重要原因,氢气具有抗ROS氧化损伤和抗炎症作用。在本研究中,我们试图证明,富氢生理盐水是否具有保护紫外线辐射皮肤损伤的效果。选择C57BL/6雌性小鼠,经UVB辐射照射引起皮肤损伤为疾病模型。给予小鼠腹腔注射富氢生理盐水和富氮生理盐水。显微镜检测伤后皮肤损害。 UVB辐射后肿瘤坏死因子α,白介素(IL-1βIL-6等炎症因子显著升高,组织超氧化物歧化酶降低,丙二醛和一氧化氮的活性升高。富氢生理盐水通过改变这些标志物的水平和改善病理改变。结果表明,富氢生理盐水可能通过减少炎症和氧化应激保护皮肤对抗紫外线辐射损伤。

J Biomed Res. 2012 Sep;26(5):365-71. doi:10.7555/JBR.26.20110037. Epub 2012 Apr 24.

Hydrogen-richsaline protects against ultraviolet B radiation injury in rats.

Guo Z, Zhou B, Li W, Sun X, Luo D.

Source

Departmentof Dermatology, the First Affiliated Hospital of Nanjing Medical University,Nanjing, Jiangsu 210029, China;

Abstract

Exposureof skin to solar ultraviolet (UV) radiation induces photo-damage. Ultraviolet B(UVB) is the major component of UV radiation which induces the production ofreactive oxygen species (ROS) and plays an important role in photo-damage.Hydrogen gas reduces ROS and alleviates inflammation. In this study, we soughtto demonstrate that hydrogen-rich saline has the effect on skin injuries causedby UVB radiation. UVB radiation was irradiated on female C57BL/6 rats to induceskin injury. Hydrogen-rich saline and nitrogen-rich saline were administered torats by intraperitoneal injection. Skin damage was detected by microscope afterinjury. UVB radiation had a significant affection in tumor necrosis factoralpha, interleukin (IL)-1β and IL-6 levels, tissue superoxide dismutase,malondialdehyde and nitric oxide activity. Hydrogen-rich saline had aprotective effect by altering the levels of these markers and relievedmorphological skin injury. Hydrogen-rich saline protected against UVB radiationinjury, possibly by reducing inflammation and oxidative stress.

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