太田成男教授是国际上最先公开发表氢气治疗疾病的著名专家。2007年在自然医学发表论文以来，已经有超过100篇氢气医学相关研究。现在正好是该论文发表4周年之际，太田教授发表了他的综述，全面总结了氢气医学相关进展，这也是他第一篇氢气医学方面的英文综述（2年前有一篇日文综述），非常值得阅读。对全面了解氢气生物医学进展是非常重要的文献。

该文章发表在Biochimica et Biophysica Acta (BBA)上。英文题目是Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases。 

Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress.pdf

本文亮点：线粒体是氧化应激的重要源泉；我们发现氢气是非常有效的新型抗氧化物质；最近许多研究确认了氢气的生物学效应；氢气本身具有特殊优点使之可能在临床应用中大显身手；本文对这方面的研究进行综述。可以说，能被该文章作为参考文献的论文将都属于该领域的奠基性的文献。

摘要：线粒体是氧化应激的重要源泉。急性氧化应激可导致严重的组织损伤，慢性持续的氧化应激是许多重要疾病例如肿瘤和衰老的共同原因；然而，过去许多年人们几乎没有发现任何没有副作用而有治疗效果抗氧化物质。我们2007年在《自然医学》上报道了氢气分子可能具有良好的临床应用前景。

本文综述了氢气在治疗和保护各类疾病和损伤方面的研究进展。自从我们在自然医学发表论文以来，在各类世界知名的生物临床医学期刊中，许多学者根据各类生理学和临床相关指标的检测，已经报道氢气可以对38类疾病具有明确的治疗作用。氢气分子的有利生物学效应可以根据这些报道确定。

给氢气的手段有许多，包括呼吸氢气、饮溶解氢气的水、用氢气进行浸泡（氢气浴，通过皮肤吸收氢气）、注射溶解氢气的生理盐水、将溶解氢气的生理盐水滴眼和通过促进大肠细菌产生氢气的方法。研究表明，氢气不仅是良好的抗氧化物质，而且具有抗炎症和抗过敏的作用。

氢气本身具有特殊优点：无任何毒性，作用广泛等，更可使氢气可能在临床应用中大显身手。初步的临床前研究表明，氢气对治疗线粒体异常类疾病具有很好的作用。

主要结论：氢气的优点使之具有良好的临床应用前景，但是氢气剂量如此小如何发挥治疗疾病效果的分子机制仍需要阐述。氢气作为新的抗氧化物质对各类急性损伤具有良好治疗价值，本文是线粒体生物化学的一个特殊议题的一部分。

Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases Biochimica et Biophysica Acta (BBA) -  Received 31 March 2011;  revised 9 May 2011;  accepted 12 May 2011.  Available online 20 May 2011.
     Highlights► Mitochondrion is one of the major sources of oxidative stress. ► We found that H2 has potential as a very effective “novel” antioxidant. ► Recent many publications have confirmed beneficial biological effects of H2. ► H2 has many advantages as potential for therapeutic and preventive applications. ► Here, I review the recent progress towards the hydrogen medicine.

Shigeo Ohta,  Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, 1–396, Kosugi-machi, Nakahara-ku, Kawasaki-city, Kanagawa-pref. 211–8533 Japan

Abstract

Background Mitochondria are the major source of oxidative stress. Acute oxidative stress causes serious damage to tissues, and persistent oxidative stress is one of the causes of many common diseases, cancer and the aging process; however, there has been little success in developing an effective antioxidant with no side effect. We have reported that molecular hydrogen has potential as an effective antioxidant for medical applications [Ohsawa et al., Nat. Med. 13 (2007) 688–694.].

Scope of review  We review the recent progress toward therapeutic and preventive applications of hydrogen. Since we published the first paper in Nature Medicine, effects of hydrogen have been reported in more than 38 diseases, physiological states and clinical tests in leading biological/medical journals.

Based on this cumulative knowledge, the beneficial biological effects of hydrogen have been confirmed. There are several ways to intake or consume hydrogen, including inhaling hydrogen gas, drinking hydrogen-dissolved water, taking a hydrogen bath, injecting hydrogen-dissolved saline, dropping hydrogen-dissolved saline into the eyes, and increasing the production of intestinal hydrogen by bacteria.

Hydrogen has many advantages for therapeutic and preventive applications, and shows not only anti-oxidative stress effects, but also has various anti-inflammatory and anti-allergic effects. Preliminary clinical trials show that drinking hydrogen-dissolved water seems to improve the pathology of mitochondrial disorders.

Major conclusions Hydrogen has biological benefits toward preventive and therapeutic applications; however, the molecular mechanisms underlying the marked effects of small amounts of hydrogen remain elusive.

General significance  Hydrogen is a novel antioxidant with great potential for actual medical applications. This article is part of a Special Issue entitled Biochemistry of Mitochondria.

Keywords: antioxidant; hydrogen; hydrogen medicine; mitochondria; oxidative stress; prevention.