氢分子医学分享 http://blog.sciencenet.cn/u/孙学军 对氢气生物学效应感兴趣者。可合作研究:sunxjk@hotmail.com 微信 hydrogen_thinker

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氢气可治疗耳聋

已有 9337 次阅读 2009-4-30 14:59 |个人分类:氢气细胞学研究|系统分类:科研笔记|关键词:氢分子医学,,氢气,hydrogen| 氢气, 氢分子医学, hydrogen

氢气能对抗内耳毛细胞氧化损伤-可治疗耳聋?

 中文摘要:

本文是氢分子医学的第16篇文献.

 

 活性氧在老化、燥声和药物毒性引起的听毛细胞退行性改变中具有重要作用。在生物体系中,氢化是氧化还原反应的基础。本研究目的是研究氢气对活性氧诱导的听毛细胞损伤的潜在作用。研究采用antimycin A方法产生活性氧,观察对体外培养的听上皮细胞,并检测氢气对抗听毛细胞活性氧的作用。结果发现,饱和氢溶液能显著减少听上皮细胞活性氧含量和脂质过氧化程度,提高听毛细胞存活数量。该研究提示,氢对保护活性氧诱导的听毛细胞具有潜在作用。

Neuroreport. 2009 May 6;20(7):689-94. Links

 

Hydrogen protects auditory hair cells from free radicals.

Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Reactive oxygen species (ROS) play a role in the degeneration of auditory hair cells because of aging, noise trauma, or ototoxic drugs. Hydrogenation is a fundamental reduction/de-oxidation reaction in living organisms. This study thus examined the potential of hydrogen to protect auditory hair cells from ROS-induced damage. To generate ROS, we applied antimycin A to explant cultures of auditory epithelia, and examined the effect of hydrogen on the protection of hair cells against ROS. Incubation with a hydrogen-saturated medium significantly reduced ROS generation and subsequent lipid peroxidation in the auditory epithelia, leading to increased survival of the hair cells. These findings show the potential of hydrogen to protect auditory hair cells from ROS-induced damage.

 

 

感谢DXY提供,
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Effect of hydrogen on the survival of cochlear hair cells. (ah) Photomicrographs of phalloidin (green) and myosin VIIa (red)-labeled cochlear cultures,treated with 0 (a and b), 0.1 (c and d), 1 (e and f), and 10 mg/ml (g and h) antimycin A (AM), with (b, d, f and h) or without (a, c, e and g) hydrogen gas(H2). Bar, 5 mm. IHCs, inner hair cells; OHCs, outer hair cells.

http://blog.sciencenet.cn/blog-41174-229111.html

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