马里兰州大学（UMD）科研团队在《自然植物》杂志上发表了一篇文章，介绍了将SpRY引入著名基因编辑工具CRISPR-Cas9。SpRY从根本上消除了有些序列不能靶向结合的障碍，使得首次针对植物中几乎所有的基因组序列进行突变成为可能。

Plant genome editing expanded with newly engineered variant of CRISPR-Cas9

https://www.sciencedaily.com/releases/2021/01/210122112320.htm

1. Qiurong Ren, Simon Sretenovic, Shishi Liu, Xu Tang, Lan Huang, Yao He, Li Liu, Yachong Guo, Zhaohui Zhong, Guanqing Liu, Yanhao Cheng, Xuelian Zheng, Changtian Pan, Desuo Yin, Yingxiao Zhang, Wanfeng Li, Liwang Qi, Chenghao Li, Yiping Qi, Yong Zhang. PAM-less plant genome editing using a CRISPR–SpRY toolbox. Nature Plants, 2021; 7 (1): 25 DOI: 10.1038/s41477-020-00827-4