科学网

 找回密码
  注册
搜索
热搜: 科学 论文
搜索
分享 Nobel Prize 2014 in Chemistry announced
袁曙光 2014-10-8 17:55
The Nobel Prize in Chemistry 2014 was awarded jointly to Eric Betzig, Stefan W. Hell and William E. Moerner for the development of super-resolved fluorescence microscopy . From http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2014/
个人分类: 科研笔记|1708 次阅读|没有评论
分享 Activation of GPCR correlates continuous water pathway
袁曙光 2014-9-9 22:01
Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway. Shuguang Yuan, Slawomir Filipek, Krzysztof Palczewski, Horst Vogel Nature Communication doi:10.1038/ncomms5733 full text news story A schemat ...
个人分类: 科研笔记|2285 次阅读|没有评论
分享 a tool for modified residues topology generation
袁曙光 2014-8-20 20:22
Most proteins undergo post translation in vivo including phosphorylation, acetylation, methylation, palmitoylation and so on. Those modified property sometimes contribute great importance on protein stability and physiological functions. However, currently, parameterizing modified covalen ...
个人分类: 科研笔记|1725 次阅读|没有评论
分享 Crystal Structure of Human free fatty-acid receptor released
袁曙光 2014-7-24 21:14
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875 Nature (2014) doi:10.1038/nature13494 Received 03 October 2013, Accepted 19 May 2014, Published online 20 July 2014 full text Abstract Human GPR40 receptor (hGPR40), also k ...
个人分类: 科研笔记|1891 次阅读|没有评论
分享 Another class C GPCR structure released
袁曙光 2014-7-10 04:37
Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant Nature (2014) doi:10.1038/nature13396 Received20 January 2014 Accepted22 April 2014 Published online06 July 2014 ...
个人分类: 科研笔记|1807 次阅读|没有评论
分享 [转载]China’s rise as a major contributor to Science & Technology
袁曙光 2014-7-5 02:23
From: China’s rise as a major contributor to Science and Technology PNAS | July 1, 2014 | vol. 111 | no. 26 | 9437–9442 In the past three decades, China has become a major contributor toscience and technology. China now employs an increasingly large labor force of scientists an ...
个人分类: 好文转载|2497 次阅读|没有评论
分享 Two MMPBSA calculation tools in Gromacs
袁曙光 2014-7-1 23:50
Molecular Mechanics- Poisson Bolzmann Surface Area (MMPBSA) is a versatile method to calculate the binding free energies of a protein/ligand complex. It incorporates the effects of thermal averaging with a force field/continuum solvent model to post-process a series of representative snapshots fr ...
个人分类: 科研笔记|9375 次阅读|没有评论
分享 install NVIDIA Optimus for laptop
袁曙光 2014-5-23 03:28
Nowadays, it is quite common and popular to have two dedicated graphic cards in laptop: usually, one is intergrated (eg: intel HD4xxx ) and the other is indepedent (eg: Nvidia GTX xxx). Such strategy can save laptop energy if we use integrated card for document task; while we can switch to inde ...
个人分类: Linux相关|5408 次阅读|没有评论
分享 convert multimedia between different formats
袁曙光 2014-5-5 04:00
Converting multimedia between different formats can be needed for different purposes. Although there are many tools under Windows, it is still feasible for such task under Linux OS including both command line and GUI end tool. Here are some popular methods for such purposes: ...
个人分类: Linux相关|2273 次阅读|没有评论
分享 Hazards Of Functional Groups
袁曙光 2014-4-18 03:12
Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. Most of the time in drug discovery are spend in optimizing compound properties including absorption, distribution, metabolism, and excretion (ADME). The four criteria all influence ...
个人分类: 科研笔记|3156 次阅读|没有评论

Archiver|手机版|科学网 ( 京ICP备14006957 )

GMT+8, 2019-11-12 16:43

Powered by ScienceNet.cn

Copyright © 2007- 中国科学报社

返回顶部