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分享 Structure of Ca2+ ion channel solved at near atomic level
袁曙光 2014-12-22 04:54
Nature (2014) doi:10.1038/nature14063 Received 12 September 2014 Accepted 12 November 2014 Published online 15 December 2014 full text: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14063.html The ryanodine receptors ...
个人分类: 科研笔记|1667 次阅读|没有评论
分享 Harvard researchers find protein that could reverse aging
袁曙光 2014-12-21 03:05
From http://www.gizmag.com By Anthony Wood Researchers from the Harvard Stem Cell Institute (HSCI) have shown that injections of a protein dubbed GDF11, when administered to older mice, appear to cause a reversal of many signs of aging. Analysis showed that every major organ ...
个人分类: 科研笔记|2104 次阅读|没有评论
分享 Merry Christmas and Happy New Year
热度 1 袁曙光 2014-12-17 05:38
个人分类: 科研笔记|1500 次阅读|1 个评论 热度 1
分享 W6.48 Opens a Gate for a Continuous Intrinsic Water Pathway
袁曙光 2014-11-18 19:33
Angew Chem Int Edit . 17/11/2014; 53(1-5). DOI: 10.1002/anie.201409679 Shuguang Yuan*, Zhenquan Hu, Slawomir Filipek, Horst Vogel* fulltext: http://onlinelibrary.wiley.com/enhanced/doi/10.1002/anie.201409679/ ABSTRACT ...
个人分类: 科研笔记|1744 次阅读|没有评论
分享 Nobel Prize 2014 in Chemistry announced
袁曙光 2014-10-8 17:55
The Nobel Prize in Chemistry 2014 was awarded jointly to Eric Betzig, Stefan W. Hell and William E. Moerner for the development of super-resolved fluorescence microscopy . From http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2014/
个人分类: 科研笔记|1793 次阅读|没有评论
分享 Activation of GPCR correlates continuous water pathway
袁曙光 2014-9-9 22:01
Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway. Shuguang Yuan, Slawomir Filipek, Krzysztof Palczewski, Horst Vogel Nature Communication doi:10.1038/ncomms5733 full text news story A schemat ...
个人分类: 科研笔记|2367 次阅读|没有评论
分享 a tool for modified residues topology generation
袁曙光 2014-8-20 20:22
Most proteins undergo post translation in vivo including phosphorylation, acetylation, methylation, palmitoylation and so on. Those modified property sometimes contribute great importance on protein stability and physiological functions. However, currently, parameterizing modified covalen ...
个人分类: 科研笔记|1780 次阅读|没有评论
分享 Crystal Structure of Human free fatty-acid receptor released
袁曙光 2014-7-24 21:14
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875 Nature (2014) doi:10.1038/nature13494 Received 03 October 2013, Accepted 19 May 2014, Published online 20 July 2014 full text Abstract Human GPR40 receptor (hGPR40), also k ...
个人分类: 科研笔记|1947 次阅读|没有评论
分享 Another class C GPCR structure released
袁曙光 2014-7-10 04:37
Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant Nature (2014) doi:10.1038/nature13396 Received20 January 2014 Accepted22 April 2014 Published online06 July 2014 ...
个人分类: 科研笔记|1866 次阅读|没有评论
分享 Two MMPBSA calculation tools in Gromacs
袁曙光 2014-7-1 23:50
Molecular Mechanics- Poisson Bolzmann Surface Area (MMPBSA) is a versatile method to calculate the binding free energies of a protein/ligand complex. It incorporates the effects of thermal averaging with a force field/continuum solvent model to post-process a series of representative snapshots fr ...
个人分类: 科研笔记|10225 次阅读|没有评论

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