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分享 First GPCR-directed antibody passes approval milestone
袁曙光 2018-7-8 02:15
Nature Reviews Drug Discovery | Published online 28 Jun 2018; doi:10.1038/nrd.2018.103 https://www.nature.com/articles/nrd.2018.103 Amgen’s erenumab recently secured FDA approval as the first G protein-coupled receptor-targeted antibody. More of these biologics are on the way, de ...
个人分类: 好文转载|927 次阅读|没有评论
分享 The first GPCR-Gi complex structure resolved
袁曙光 2018-6-15 01:02
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein Nature (2018) Published:13 June 2018 Abstract G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with d ...
个人分类: 好文转载|1393 次阅读|没有评论
分享 圣诞与新年快乐
袁曙光 2017-12-14 00:45
个人分类: 好文转载|1200 次阅读|没有评论
分享 a postdoc position
袁曙光 2016-6-19 16:16
About the Agency for Science, Technology and Research (A*STAR) The Agency for Science, Technology and Research (A*STAR) is Singapore's lead public sector agency that spearheads economic oriented research to advance scientific discovery and develop innovative technology. Through open innovati ...
个人分类: 好文转载|1646 次阅读|没有评论
分享 Crystal structures of adiponectin receptors released
热度 1 袁曙光 2015-4-17 21:12
Nature 520, 312–316 (16 April 2015) doi:10.1038/nature14301 Full text Abstract Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of 5′ AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR), respectively, thereby c ...
个人分类: 好文转载|1521 次阅读|2 个评论 热度 1
分享 2014 FDA drug approvals
袁曙光 2015-2-9 18:32
From Nature Reviews Drug Discovery 14, 77–81(2015) doi:10.1038/nrd4545 Drug (brand name) Sponsor Properties Indications Review types Dapagliflozin (Farxiga) AstraZeneca SGLT2 inhibitor Type 2 diabetes S Tasimelteon (Hetlioz) Vanda Melatonin-receptor agonist ...
个人分类: 好文转载|2191 次阅读|没有评论
分享 BioVersys works to bring antinbiotic resistance to an end
袁曙光 2014-12-18 23:43
From http://www.venturekick.ch 9 December 2014 - In May this year, BioVersys started a project in collaboration with Lille University and GlaxoSmithKline to develop a preclinical candidate for the treatment of tuberculosis, a disease that alone kills more than 1.5 million people each ...
个人分类: 好文转载|1525 次阅读|没有评论
分享 Show me the money
袁曙光 2014-10-29 02:47
Science 24 October 2014: Vol. 346 no. 6208 pp. 411-415 DOI: 10.1126/science.346.6208.411 Feature by Mara Hvistendahl* original full txt: http://www.sciencemag.org/content/346/6208/411.full#fn-1 In a hotel room on the sidelines of a conference in China in 2011, theoretical ...
个人分类: 好文转载|2369 次阅读|没有评论

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