A self-balancing circuit centered on MoOsm1 kinase governs adaptive responses to host-derived ROS in Magnaporthe oryzae

第一作者：Xinyu Liu

第一单位：南京农业大学

通讯作者：Zhengguang Zhang

 Abstract 

背景回顾：The production of reactive oxygen species (ROS) is a ubiquitous defense response in plants. Adapted pathogens evolved mechanisms to counteract the deleterious effects of host-derived ROS and promote infection.

提出问题：How plant pathogens regulate this elaborate response against ROS burst remains unclear.

主要发现：Using the rice blast fungus Magnaporthe oryzae, we uncovered a self-balancing circuit controlling response to ROS in planta and virulence. 

Circuit-1：During infection, ROS induces phosphorylation of the high osmolarity glycerol pathway kinase MoOsm1 and its nuclear translocation.

Circuit-2：There, MoOsm1 phosphorylates transcription factor MoAtf1 and dissociates MoAtf1-MoTup1 complex.

Circuit-3：This releases MoTup1-mediated transcriptional repression on oxidoreduction-pathway genes and activates the transcription of MoPtp1/2 protein phosphatases.

Circuit-4：In turn, MoPtp1/2 dephosphorylate MoOsm1, restoring the circuit to its initial state.

结果：Balanced interactions among proteins centered on MoOsm1 provide a means to counter host-derived ROS.

结论：Our findings thereby reveal new insights into how M. oryzae utilizes a phosphor-regulatory circuitry to face plant immunity during infection.

 通讯作者 

doi: https://doi.org/10.7554/eLife.61605

Journal: eLife

Published date: Dec 04, 2020