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The atypical histone variant H3.15 promotes callus formation in Arabidopsis thaliana

第一作者An Yan


通讯作者Zhong Chen


背景回顾Plants are capable of regenerating new organs after mechanical injury.

研究基础:The regeneration process involves genome-wide reprogramming of transcription, which usually requires dynamic changes in the chromatin landscape.

主要发现:We show that the histone 3 variant, HISTONE THREE RELATED 15 (H3.15), plays an important role in cell fate reprogramming during plant regeneration in Arabidopsis

试验结果:H3.15 expression is rapidly induced upon wounding. Ectopic overexpression of H3.15 promotes cell proliferation to form a larger callus at the wound site, while htr15 mutation compromises callus formation. H3.15 is distinguished from other Arabidopsis histones by the absence of the lysine residue 27 that is trimethylated by the POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) in constitutively expressed H3 variants. Overexpression of H3.15 promotes the removal of the transcriptional repressive mark H3K27me3 from chromatin, which results in transcriptional derepression of downstream genes such as WUSCHEL RELATED HOMEOBOX11 (WOX11).

结论:Our results reveal a new mechanism for a release from PRC2-mediated gene repression through H3.15 deposition into chromatin, which is involved in reprogramming cell fate to produce pluripotent callus cells.

 摘  要 


Proposed model of the role of the H3.15 pathway in plant regeneration.

doi: 10.1242/dev.184895

Journal: Development

First Published: May 21, 2020

p.s. 往期相关研究:


下一篇:Nature Communications:山羊草胚胎发生早期根组织程序性消除B套染色体


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