A Jasmonate Signaling Network Activates Root Stem Cells and Promotes Regeneration

First author: Wenkun Zhou; Affiliations: Wageningen University and Research (瓦格宁根大学): Wageningen, the Netherlands

Corresponding author: Ben Scheres

Plants are sessile and have to cope with environmentally induced damage through modification of growth and defense pathways. How tissue regeneration is triggered in such responses and whether this involves stem cell activation is an open question. The stress hormone jasmonate (JA) plays well-established roles in wounding and defense responses. JA also affects growth, which is hitherto interpreted as a trade-off between growth and defense. Here, we describe a molecular network triggered by wound-induced JA that promotes stem cell activation and regeneration. JA regulates organizer cell activity in the root stem cell niche through the RBR-SCR network and stress response protein ERF115. Moreover, JA-induced ERF109 transcription stimulates CYCD6;1 expression, functions upstream of ERF115, and promotes regeneration. Soil penetration and response to nematode herbivory induce and require this JA-mediated regeneration response. Therefore, the JA tissue damage response pathway induces stem cell activation and regeneration and activates growth after environmental stress.

植物属于固着生物，所以必须通过调整生长和防御通路来应付由外界环境造成的损伤。组织再生的诱导就是植物应对的响应之一，该过程是否涉及干细胞的激活一直是一个悬而未决的问题。胁迫激素茉莉酸JA在植物受伤和防御响应过程中扮演非常重要的作用。迄今为止，JA被认为通过植物的生长和防御之间的平衡来影响植物的生长。本文，作者报道了由损伤诱导的JA触发的分子调控网络促进干细胞的激活和再生。JA通过RBR-SCR网络和胁迫响应蛋白ERF115来调控根干细胞龛中组织者细胞的活性。此外，JA诱导的ERF109转录会刺激CYCD6;1的表达，在ERF115的上游发挥作用，促进再生。土壤渗透和响应食草类线虫会诱导这类JA介导的再生响应，并且植物也需要这种响应来应对胁迫。因此，JA介导的植物组织损伤响应通路诱导干细胞的激活和再生，并激活植物在渡过环境胁迫后的生长。

通讯：Ben Scheres (https://www.wur.nl/en/Persons/Ben-prof.dr.ir.-BJG-Ben-Scheres.htm)

研究方向：利用拟南芥等模式植物研究模式建成、细胞极性建立以及细胞周期相关的分子调控机制。

doi: https://doi.org/10.1016/j.cell.2019.03.006

Journal: Cell

Published date: April 04, 2019