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地中海贫血症基因疗法的知识发现与信息分析

已有 3505 次阅读 2010-9-20 15:05 |个人分类:遗传病学|系统分类:论文交流| 基因疗法, 地中海贫血症

自然》:地中海贫血症基因疗法试验初获成功

http://news.sciencenet.cn/htmlnews/2010/9/237790.shtm

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

 

Start A-Literature C-Literature B-list Filter Literature
  A-query: Gene therapy AND
C-query: HMGA2
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 19 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 4759 and can be accessed from the start page after you leave this session. There are 320 terms on the current B-list (164 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 

job id # 4759 started Mon Sep 20 03:18:36 2010
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
4759 Search ARROWSMITH A
4759 Search ARROWSMITH A
A_query_raw: Gene therapy AND Mon Sep 20 03:19:06 2010

A query = Gene therapy AND started Mon Sep 20 03:19:06 2010
A query resulted in 50000 titles
4759 Search ARROWSMITH C
C_query_raw: HMGA2 Mon Sep 20 03:20:03 2010

C: HMGA2 459

A: pubmed_query_A 115839

AC: ( Gene therapy AND ) AND ( HMGA2 ) 19

C query = HMGA2 started Mon Sep 20 03:20:03 2010
C query resulted in 459 titles
A AND C query resulted in 19 titles
2453 B-terms ready on Mon Sep 20 03:22:28 2010

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
320 B-terms left after filter executed Mon Sep 20 03:27:21 2010

请专家看看这些基因是否有研究价值?

B-list on Mon Sep 20 03:28:16 2010
1 fhit
2 wnt
3 mdm2
4 e2f1
5 brca1
6 let-7
7 stat3
8 wt1
9 smad
10 gene wt1
11 ppargamma
12 differentially expressed gene
13 ercc1
14 phosphatidylinositol 3-kinase
15 wilm tumor gene
16 braf
17 cdk4
18 sp1
19 tumor gene wt1
20 estrogen receptor beta
21 microrna
22 smad3
23 cd34
24 bcl-2 gene
25 zinc finger protein
26 galectin
27 il-15
28 p16ink4a
29 ret
30 c jun n
31 exon
32 genome wide
33 bfl-1
34 bcl-2
35 c jun
36 ink4a
37 chemokine
38 intron
39 nf kappab
40 snp
41 promoter a
42 q11
43 tumor suppressor gene
44 intronic
45 candidate gene
46 tsc2
47 histone deacetylase
48 high mobility group
49 il-2
50 p13
51 ap-1
52 rhoa
53 promoter region
54 cdna
55 allele specific
56 p19arf
57 transcription factor
58 b16
59 promyelocytic leukemia
60 responsive gene
61 wilm tumor
62 tumor gene
63 raf-1
64 tgf beta
65 cyclin
66 igf
67 junb
68 cml
69 hmga
70 beta gene
71 gene transcript
72 proximal promoter
73 gene uterine
74 nf kappa b
75 group protein gene
76 estrogen receptor
77 q15
78 promoter analysis
79 dna repair gene
80 tgfbeta1
81 igf i
82 tumor suppressor
83 p21
84 q14
85 ret ptc1 rearrangement
86 chemokine gene
87 p53
88 arf
89 cdc2
90 gene expressed
91 genomic profiling
92 hipk2
93 rante
94 oncogene
95 breakpoint cluster region
96 serine threonine kinase
97 fusion oncogene
98 raf
99 gene family
100 expression gene
101 q13
102 cdc42
103 suppressor gene
104 novel gene
105 cgh
106 jun
107 pcr
108 promoter dna
109 h ras
110 p24
111 gene transgenic
112 related gene
113 fra-1
114 igf1
115 adiposity
116 protein gene
117 gene solid tumor
118 rac1
119 proto oncogene
120 retinoblastoma
121 rna binding protein
122 bone mineral density
123 insulin growth factor
124 nf
125 synovial
126 ctip
127 gene encoding
128 collagen gene
129 isoform
130 breakpoint
131 hmga1
132 pias3
133 rna binding
134 allele
135 tumor associated gene
136 protein kinase
137 c gene
138 promoter
139 oncogene tumor
140 activin
141 gene human
142 glioma
143 histone h1
144 gene ercc1
145 p19
146 gene coding
147 box
148 nf-1
149 gene amplified
150 untranslated region
151 ras
152 ink4a arf
153 gene related
154 genomic
155 copy
156 metalloprotease
157 body mass index
158 prostate cancer
159 gene transgenic mice
160 binding protein gene
161 tumor suppressor microrna
162 senescence
163 histone

 

Start A-Literature C-Literature B-list Filter Literature

AB literature

 

B-term

 

BC literature

 

Gene therapy AND fhit HMGA2
1: TRAIL-induced apoptosis of<font color="green"><b> FHIT</font></b>-negative lung cancer cells is inhibited by<font color="green"><b> FHIT</font></b> re-expression. 2009
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2: <font color="green"><b>[FHIT</font></b>--tumor suppressor protein involved in induction of apoptosis and cell cycle regulation] 2009
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3: Enlightened protein:<font color="green"><b> Fhit</font></b> tumor suppressor protein structure and function and its role in the toxicity of protoporphyrin IX-mediated photodynamic reaction. 2009
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4: <font color="green"><b>Fhit</font></b> regulates invasion of lung tumor cells. 2009
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5: <font color="green"><b>Fhit</font></b> interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells. 2008
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6: <font color="green"><b>Fhit</font></b> tumor suppressor: guardian of the preneoplastic genome. 2008
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7: Tumor suppressor<font color="green"><b> Fhit</font></b> protein interacts with protoporphyrin IX in vitro and enhances the response of HeLa cells to photodynamic therapy. 2007
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8: A<font color="green"><b> Fhit</font></b>-ing role in the DNA damage checkpoint response. 2007
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9: Increased sensitivity to cisplatin in non-small cell lung cancer cell lines after<font color="green"><b> FHIT</font></b> gene transfer. 2006
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10: Preclinical assessment of<font color="green"><b> FHIT</font></b> gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35. 2006
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11: <font color="green"><b>Fhit</font></b> modulates the DNA damage checkpoint response. 2006
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12: A mouse model of the fragile gene<font color="green"><b> FHIT</font></b>: From carcinogenesis to gene therapy and cancer prevention. 2005
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1: Expression of reciprocal hybrid transcripts of HMGIC and FHIT in a pleomorphic adenoma of the parotid gland. 1997
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http://www.gopubmed.org/web/gopubmed/1?WEB1mOWEB10O00d000j10020001000h00100090000

Gene therapy   AND  β-thalassaemia

395 documents semantically analyzed
 
1 2 
Top Years
Publications
 
2003
 
31
2007
 
29
2008
 
27
2009
 
26
2005
 
25
2010
 
23
2006
 
23
2000
 
23
2001
 
22
2002
 
21
2004
 
20
1998
 
18
1999
 
13
1996
 
13
1995
 
12
1991
 
11
1994
 
10
1997
 
8
1993
 
6
1990
 
5
1 2 
 
1 2 
Top Countries
Publications
 
USA
 
148
China
 
36
Italy
 
34
United Kingdom
 
23
France
 
15
India
 
13
Greece
 
12
Canada
 
10
Australia
 
8
Israel
 
8
Thailand
 
6
Iran
 
5
Japan
 
5
Germany
 
4
Netherlands
 
3
Turkey
 
3
Egypt
 
2
Cyprus
 
2
Malaysia
 
2
Taiwan
 
2
1 2 
 
1 2 3 ...6 
Top Cities
Publications
 
New York City
 
30
Memphis
 
15
London
 
13
Beijing, China
 
13
Boston
 
12
Shanghai, China
 
11
Seattle
 
11
Los Angeles
 
10
Paris
 
10
Philadelphia
 
9
Athens
 
8
Chapel Hill
 
8
Bethesda
 
8
Melbourne
 
7
Guangzhou
 
7
Ferrara
 
6
Jerusalem
 
6
Mumbai
 
5
Milan
 
5
Cagliari
 
5
1 2 3 ...6 
 
1 2 3 ...9 
Top Journals
Publications
 
Blood
 
32
Ann N Y Acad Sci
 
22
Br J Haematol
 
17
Haematologica
 
14
Proc Natl Acad Sci U S A
 
12
Hemoglobin
 
11
Am J Hematol
 
10
Mol Ther
 
9
Exp Hematol
 
8
Semin Hematol
 
8
Blood Cells Mol Dis
 
7
Eur J Haematol
 
6
Hematology Am Soc Hematol Educ Program
 
5
Int J Hematol
 
5
Hum Gene Ther
 
4
Science
 
4
Hum Mol Genet
 
4
N Engl J Med
 
4
Hematology
 
4
Baillieres Clin Haematol
 
4
1 2 3 ...9 
 
1 2 3 ...126 
Top Terms
Publications
 
Genes
 
347
Humans
 
346
beta-Thalassemia
 
345
Globins
 
279
Patients
 
211
Gene Therapy
 
184
Thalassemia
 
176
Hemoglobins
 
158
oxygen transporter activity
 
151
Animals
 
144
Mutation
 
127
Adult
 
119
Mice
 
114
Stem Cells
 
102
gene expression
 
101
Anemia, Sickle Cell
 
99
Therapeutics
 
96
Fetal Hemoglobin
 
96
Gene Expression
 
93
stem cell development
 
87
1 2 3 ...126 
 
1 2 3 ...76 
Top Authors
Publications
 
Sadelain M
 
14
Persons D
 
10
Bank A
 
9
Rivella S
 
9
Nienhuis A
 
9
Vadolas J
 
8
Thein S
 
8
Stamatoyannopoulos G
 
7
Fucharoen S
 
7
Rodgers G
 
7
Humphries R
 
7
Beuzard Y
 
7
Huang S
 
6
Malik P
 
6
Liang C
 
6
Liu D
 
6
LeBoulch P
 
6
Perrine S
 
6
FABRY M
 
6
Nagel R
 
6
1 2 3 ...76 

 

 

 

 

 

 



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