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SWI/SNF 调控肿瘤免疫
王建秋 2019-12-22 16:13
1、SWI/SNF :一种ATP依赖的染色质重塑复合物 rhabdoid tumors(横纹肌瘤):根据发生部位分为颅内的非典型畸胎瘤样横纹肌瘤(ATRTs),和颅外的恶性横纹肌瘤(MRTs),均存在非常一致且明确的SMARCB1(SWI/SNF复合体的一个核心亚基)双等位基因的失活。除此之外,横纹肌瘤的基因组相当quiet而没有其他已知的的致癌驱动突 ...
个人分类: 科研笔记|5004 次阅读|没有评论
Cold and hot tumor; 肿瘤突变负荷(TMB)
王建秋 2019-12-22 14:32
1、Cold tumor 与hot tumor 肿瘤浸润淋巴细胞(tumor infiltrating lymphocytes, TILs)可介导肿瘤的免疫治疗,包括各类血液细胞,这些细胞能够从血流中迁移到肿瘤组织内,其中T淋巴细胞是主要的抗肿瘤免疫细胞。并非每个肿瘤组织中都有TILs细胞存在,有的肿瘤标本中有大量TILs,有的标本中只有少量甚至没 ...
7831 次阅读|没有评论
Numpy Installation: Python 2.7 required, which was not found
王建秋 2013-1-8 21:40
To use HTSeq, a tool for high-throughput sequencing data analysis, I need install Python 2.7 and Numpy on 64-bit windows 7. Python 2.7 was first successfully installed. But during the installation of Numpy_1.6, erroroccurred:Python version 2.7 required, which was not found in the registr ...
个人分类: 科研笔记|6281 次阅读|没有评论
qRT-PCR: Oligo(dT) primer or Random hexamers?
王建秋 2013-1-8 21:10
Oligo dT and random hexamers are two different primers used in reverse transcription reactions for subsequent real-time PCR for gene expression. I usually use oligo dT primers. But in the lab I stayed now, random hexamers were used by everyone except me. The expression levels of genes varied with t ...
个人分类: 科研笔记|5938 次阅读|没有评论

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