许培扬 微生物组国际研究前沿热点分析报告 http://blog.sciencenet.cn/home.php?mod=space&uid=280034&do=blog&id=977258
2016-05-15
microbiome 美政府启动“国家微生物组计划” 新华社华盛顿５月１３日电（记者林小春）美国奥巴马政府１３日宣布启动“国家微生物组计划”，旨 ...
微生物组国际研究前沿与热点主题分布如下：
01.soil pollutants 83 篇3.26388 02.microbiota 3526 篇2.65135 03.immunity, mucosal 283 篇0.335173 04.bacteroidetes 146 篇0.271706 05.prognosis 92 篇0.236948 06.bacterial translocation 89 篇0.223619 07.virulence 91 篇0.181964 08.case-control studies 299 篇0.101217 09.dysbiosis 195 篇0.0905934 10.reproducibility of results 80 篇0.0836504 11.actinomyces 80 篇0.0627378 12.random allocation 97 篇0.0447149 13.double-blind method 189 篇0.0401522 14.follow-up studies 140 篇0.0401522 15.anaerobiosis 103 篇0.0377903 16.germ-free life 283 篇0.0369583 17.prevotella intermedia 79 篇0.0328518 18.administration, oral 108 篇0.0258121 19.cross-sectional studies 97 篇0.0228137 20.mice, inbred balb c 198 篇0.0200761 21.prospective studies 161 篇0.0150571 22.molecular sequence data 819 篇0.00501902 24.signal transduction 335 篇8.43001 25.hiv infections 89 篇7.33176 27.anti-bacterial agents 890 篇6.26936 30.gene expression regulation 162 篇5.0048 31.bacterial proteins 300 篇4.90504 32.colorectal neoplasms 137 篇4.59909 33.phylogeny 1129 篇4.44478 35.diabetes mellitus, type 2 121 篇3.89156 38.genetic predisposition to disease 134 篇3.57998 39.inflammation 530 篇3.40707 40.plant extracts 99 篇3.3776 41.models, biological 304 篇3.35436 42.cell differentiation 89 篇3.33377 45.bacteria 2872 篇2.87141 46.macrophages 83 篇2.68843 47.cell proliferation 90 篇2.66113 50.escherichia coli 337 篇2.40559 51.ecosystem 363 篇2.29075 52.genetic variation 219 篇2.2163 53.biological markers 105 篇2.07015 55.soil microbiology 329 篇1.90805 56.epithelial cells 157 篇1.90782 57.cytokines 296 篇1.86929 58.t-lymphocytes 118 篇1.82491 59.dendritic cells 130 篇1.81139 61.immunity, innate 411 篇1.73178 62.anti-inflammatory agents 79 篇1.6904 63.biodiversity 735 篇1.6695 64.rna, messenger 113 篇1.62348 65.geologic sediments 73 篇1.61754 66.disease models, animal 439 篇1.55612 67.biological evolution 118 篇1.46904 68.tumor necrosis factor-alpha 114 篇1.45731 69.cd4-positive t-lymphocytes 73 篇1.43323 70.body mass index 85 篇1.43127 71.insulin resistance 107 篇1.42187 72.gene expression regulation, bacterial 121 篇1.40756 73.immunoglobulin g 71 篇1.4037 74.intestines 2013 篇1.3952 75.host-pathogen interactions 448 篇1.38635 76.t-lymphocytes, regulatory 123 篇1.38049 77.gene expression profiling 163 篇1.37089 78.dietary supplements 227 篇1.35758 80.energy metabolism 135 篇1.29859 81.sequence analysis, dna 1017 篇1.2917 83.crohn disease 228 篇1.26799 84.diabetes mellitus, type 1 73 篇1.2471 85.intestinal mucosa 924 篇1.22405 87.computational biology 138 篇1.19761 88.metabolic syndrome x 92 篇1.19051 89.high-throughput nucleotide sequencing 191 篇1.1303 91.homeostasis 301 篇1.10483 92.food microbiology 285 篇1.09736 93.anti-infective agents 109 篇1.09345 94.chromatography, high pressure liquid 106 篇1.07399 95.blood glucose 73 篇1.06228 96.staphylococcus aureus 96 篇1.05789 97.bioreactors 92 篇1.05782 98.severity of illness index 93 篇1.05086 100.biofilms 274 篇1.03039 101.mass spectrometry 85 篇1.02706 102.bacterial infections 221 篇0.997385 103.lipid metabolism 78 篇0.997046 105.phenotype 175 篇0.947359 106.polysaccharides 103 篇0.920472 107.drug resistance, bacterial 181 篇0.918407 108.colitis, ulcerative 191 篇0.915233 109.gene expression 99 篇0.910953 110.interleukin-6 77 篇0.898911 111.gastrointestinal tract 1977 篇0.883763 113.fatty acids 162 篇0.88005 114.chronic disease 164 篇0.879979 115.temperature 132 篇0.858822 116.environment 81 篇0.823038 117.water microbiology 164 篇0.819985 118.metabolomics 151 篇0.816525 119.th17 cells 75 篇0.79191 120.inflammatory bowel diseases 521 篇0.74844 122.polymerase chain reaction 752 篇0.729905 123.genome, bacterial 188 篇0.724446 124.plant roots 81 篇0.723996 125.diarrhea 158 篇0.710309 126.probiotics 1251 篇0.703896 127.inflammation mediators 102 篇0.698227 128.hypersensitivity 125 篇0.693329 129.interferon-gamma 71 篇0.6605 130.dermatitis, atopic 78 篇0.648042 131.real-time polymerase chain reaction 169 篇0.63304 133.dietary fats 93 篇0.623363 134.gastrointestinal diseases 153 篇0.615233 135.body weight 129 篇0.60919 136.food handling 83 篇0.606831 137.lipopolysaccharides 125 篇0.606113 138.symbiosis 469 篇0.60133 139.intestine, small 176 篇0.595835 140.diet, high-fat 96 篇0.59495 141.genotype 135 篇0.593318 142.breast feeding 113 篇0.565389 144.interleukin-10 134 篇0.564573 145.toll-like receptor 4 77 篇0.550358 146.irritable bowel syndrome 185 篇0.534304 147.dna, bacterial 1304 篇0.534199 148.magnetic resonance spectroscopy 73 篇0.524596 149.immune tolerance 122 篇0.512197 150.helicobacter pylori 71 篇0.507398 151.escherichia coli infections 76 篇0.498383 152.disease progression 110 篇0.488287 153.salmonella typhimurium 87 篇0.486582 154.weight gain 95 篇0.484564 155.helicobacter infections 79 篇0.474378 156.lactic acid 110 篇0.467177 157.adaptive immunity 126 篇0.464165 159.pregnancy 292 篇0.438465 160.clostridium difficile 239 篇0.423503 161.dental implants 73 篇0.412732 162.virulence factors 77 篇0.406541 163.toll-like receptors 97 篇0.396072 164.fermentation 562 篇0.386569 165.oligosaccharides 270 篇0.385135 166.bacteriological techniques 112 篇0.382249 167.bile acids and salts 100 篇0.369031 168.metabolome 131 篇0.365739 170.metabolic networks and pathways 84 篇0.364296 171.archaea 149 篇0.363054 172.polyphenols 71 篇0.358658 174.treatment outcome 300 篇0.350678 177.clostridium infections 148 篇0.340072 179.bacterial physiological phenomena 259 篇0.337853 181.candida albicans 73 篇0.31542 182.animal feed 241 篇0.312846 184.immune system 162 篇0.311393 185.flow cytometry 107 篇0.310542 186.oligonucleotide array sequence analysis 113 篇0.310425 187.digestion 110 篇0.296632 188.dental caries 97 篇0.291475 189.models, animal 98 篇0.281729 190.milk, human 130 篇0.2814 191.lactobacillus 699 篇0.276674 192.culture media 155 篇0.266031 193.gram-negative bacteria 157 篇0.263146 194.bacterial adhesion 141 篇0.257353 195.metagenomics 332 篇0.252336 196.microbial viability 76 篇0.242741 197.periodontal diseases 139 篇0.242131 198.dietary carbohydrates 105 篇0.241582 199.rna, ribosomal, 16s 1673 篇0.238455 201.in situ hybridization, fluorescence 204 篇0.235239 202.rna, bacterial 265 篇0.229035 203.immunoglobulin a 122 篇0.22532 204.gram-positive bacteria 198 篇0.221339 205.bifidobacterium 642 篇0.219055 206.dietary fiber 185 篇0.217717 207.genes, bacterial 227 篇0.213683 208.intestinal diseases 95 篇0.208731 210.enterobacteriaceae 167 篇0.204762 211.disease susceptibility 101 篇0.201093 213.age factors 129 篇0.196308 215.reverse transcriptase polymerase chain reaction 126 篇0.194234 218.periodontitis 291 篇0.176229 220.actinobacteria 103 篇0.17071 221.enterocolitis, pseudomembranous 114 篇0.165367 222.cloning, molecular 84 篇0.162869 223.enterococcus 91 篇0.152588 224.biodegradation, environmental 131 篇0.152455 225.microbial interactions 107 篇0.138827 226.streptococcus 182 篇0.136166 227.staphylococcus 91 篇0.13305 228.dna, fungal 90 篇0.131863 229.prebiotics 349 篇0.130707 230.dna fingerprinting 138 篇0.128891 231.immunity 79 篇0.123155 232.dna primers 176 篇0.120758 233.clostridium 213 篇0.119351 234.biological therapy 95 篇0.118498 235.dna, ribosomal 439 篇0.117845 237.molecular typing 80 篇0.113026 238.oxidation-reduction 104 篇0.111724 239.infant formula 93 篇0.109772 240.cluster analysis 346 篇0.104074 241.mucous membrane 75 篇0.102658 242.animal nutritional physiological phenomena 110 篇0.100555 243.bacterial load 178 篇0.0997957 244.microbial sensitivity tests 201 篇0.0951995 245.nucleic acid hybridization 84 篇0.0918608 246.base sequence 300 篇0.0892407 247.antibiosis 92 篇0.08721 248.butyrates 94 篇0.084619 249.polymorphism, restriction fragment length 203 篇0.0828829 250.porphyromonas gingivalis 195 篇0.0765253 251.gingiva 154 篇0.0755652 252.gene library 102 篇0.0747795 253.animals, newborn 106 篇0.0732067 254.genes, rrna 142 篇0.073004 255.principal component analysis 127 篇0.0711357 256.bacteria, anaerobic 176 篇0.0710536 257.cohort studies 120 篇0.0704424 258.metagenome 1772 篇0.0675823 259.gingivitis 83 篇0.0657036 260.bacterial typing techniques 178 篇0.0601109 261.hydrogen-ion concentration 264 篇0.0598723 262.colony count, microbial 685 篇0.0566208 264.bacteroides 398 篇0.0484856 265.fatty acids, volatile 249 篇0.0481171 266.vaginosis, bacterial 118 篇0.0447149 267.proteobacteria 111 篇0.0431744 268.longitudinal studies 107 篇0.0377903 269.dental plaque 387 篇0.0373724 270.intestine, large 78 篇0.0352019 271.cell line 88 篇0.0347471 272.mice, knockout 257 篇0.0279319 273.recurrence 94 篇0.0253042 274.species specificity 353 篇0.0237939 275.weaning 83 篇0.0226144 276.mice, transgenic 71 篇0.0200761 277.digestive system 143 篇0.0195335 278.fusobacterium nucleatum 87 篇0.0163955 279.periodontal pocket 166 篇0.0157117 280.periodontal index 94 篇0.014905 281.permeability 77 篇0.014905 282.pilot projects 80 篇0.0146008 283.electrophoresis, polyacrylamide gel 137 篇0.0139417 284.cells, cultured 125 篇0.0125476 285.time factors 390 篇0.0122966 286.rats, sprague-dawley 141 篇0.0107072 287.denaturing gradient gel electrophoresis 169 篇0.0104563 288.sensitivity and specificity 88 篇0.010038 289.analysis of variance 143 篇0.00803044 290.prevotella 100 篇0.00694942 291.risk factors 369 篇0.00694942 292.prevalence 109 篇0.00669203 293.mice, inbred c57bl 577 篇0.00594847 294.amino acid sequence 87 篇0.00512145 295.statistics, nonparametric 155 篇0.00376427 296.rats, wistar 123 篇0.00122979 297.cross-over studies 96 篇0.000546572
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