Science发布再生医学重要发现

内皮细胞并不仅仅只会对外源性刺激做出被动响应，它们自身还以一种非常积极的方式控制了器官功能。现在来自德国癌症研究中心和海德堡大学的科学家们发现，在遭受损伤或部分手术切除之后内皮细胞可通过一种复杂的生长调控机制来控制肝脏再生。

在上调和下调的基因中，Angiopoietin-2 (Ang2)被确定为是肝脏再生的一个关键调控因子。

 http://www.ebiotrade.com/newsf/read.asp?page=2014220130725619

知识发现平台  http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

A-query: Angiopoietin-2
C-query: Liver Regeneration

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 3 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 2360 and can be accessed from the start page after you leave this session. There are 360 terms on the current B-list (73 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

job id # 2360 started Sat Feb 22 01:31:59 2014
Max_citations: 50000
Stoplist: /var/www/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
A_query_raw: Angiopoietin-2 Sat Feb 22 01:32:06 2014

A query = Angiopoietin-2 started Sat Feb 22 01:32:06 2014
A query resulted in 1558 titles
C_query_raw: Angiopoietin-2 Sat Feb 22 01:32:09 2014

C: Angiopoietin-2 1558

A: pubmed_query_A 1558

AC: ( Angiopoietin-2 ) AND ( Angiopoietin-2 ) 1558

C_query_raw: Liver Regeneration Sat Feb 22 01:32:28 2014

C: Liver Regeneration 15153

A: pubmed_query_A 1558

AC: ( Angiopoietin-2 ) AND ( Liver Regeneration ) 3

C_query_raw: Liver Regeneration Sat Feb 22 01:32:31 2014

C: Liver Regeneration 15153

A: pubmed_query_A 1558

AC: ( Angiopoietin-2 ) AND ( Liver Regeneration ) 3

C query = Liver Regeneration started Sat Feb 22 01:32:31 2014
C query resulted in 15153 titles
A AND C query resulted in 3 titles
3985 B-terms ready on Sat Feb 22 01:32:41 2014

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
360 B-terms left after filter executed Sat Feb 22 01:33:29 2014

B-list on Sat Feb 22 01:39:59 2014
1 angiopoietin
2 akt
3 vegf
4 cox-2
5 cd34
6 endostatin
7 cdna
8 beta catenin
9 cd133
10 stat3
11 growth factor gene
12 receptor tyrosine kinase
13 activin
14 toll receptor
15 hepatocyte growth factor
16 c jun
17 mtor
18 survivin
19 adiponectin
20 transcription factor
21 sonic hedgehog
22 at1
23 matrix metalloproteinase
24 tyrosine kinase
25 c myc
26 oncostatin m
27 ets
28 interleukin
29 expression gene
30 flt-1
31 cannabinoid receptor
32 fibroblast growth factor
33 e2f1
34 cyclin d1
35 leptin
36 cadherin
37 tnf alpha
38 myc
39 ha ras
40 il-6
41 p53
42 hedgehog
43 receptor flt-1
44 factor gene
45 angiotensin receptor
46 notch3
47 erythropoietin
48 tumor suppressor
49 jak stat
50 bcl-2
51 p38
52 notch1
53 jak2
54 nf kappab
55 tnf
56 cxcr4
57 epidermal growth factor
58 metabolic syndrome
59 related gene
60 cytokine
61 erk1
62 mmp-9
63 integrin
64 gene transfer
65 tumstatin
66 tyrosine phosphatase
67 hif-1alpha
68 socs3
69 islet
70 insulin growth factor
71 jun
72 cell cycle progression
73 tumor necrosis factor

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=2360

信息分析平台  http://www.pubmedplus.cn/Pubmed/Statistic