博文

韩春雨《自然》论文新进展

已有 4696 次阅读 2017-1-19 16:22 |个人分类:今日热点|系统分类:观点评述

Nature报道丹麦诺维信公司与河北科技大学NgAgo基因编辑技术合作

http://blog.sciencenet.cn/blog-71079-1029007.html

韩春雨副教授所在的河北科技大学，在其官网发布新闻，宣布河北科技大学基因编辑技术研究中心与丹麦诺维信公司，就ngago技术的应用与开发达成合作并签署协议，并称“双方对尽快合作推动该成果的产业化实现充满信心”。据介绍，诺维信公司是全球工业酶制剂和微生物制剂的主导企业，迄今已连续十多年在道琼斯可持续发展指数方面处于领导者地位。河北科技大学还表示该校“基因编辑技术研究中心积极推进以argonaute核酸酶为核心的基因编辑技术开发及其相关知识产权的转化和应用。目前的基因编辑技术专利主要由美国持有，韩春雨团队发现的基因编辑工具ngago-gdna为基因编辑技术提供了新的选择。”

8 Aug 2016

Replications, ridicule and a recluse: the controversy over NgAgo...

www.nature.com/news/replications-ridicule-and-a-recluse-the-controversy-over-ngago-gene-editing-intensifies-1.20387

23 Nov 2016

Updated: NgAgo gene-editing controversy escalates in peer -...

www.nature.com/news/updated-ngago-gene-editing-controversy-escalates-in-peer-reviewed-papers-1.21023

20 Jan 2017

Enzyme firm invests in NgAgo protein at centre of gene-editing...

www.nature.com/news/enzyme-firm-invests-in-ngago-protein-at-centre-of-gene-editing-row-1.21343

韩春雨论文被引量大增

http://blog.sciencenet.cn/blog-280034-1018406.html

DNA-guided genome editing using the Natronobacterium gregoryi Argonaute
Feng Gao · Xiao Z Shen · Feng Jiang · Yongqiang Wu · Chunyu Han
2016 · Nature Biotechnology|被引数：35
NgAgo-gDNA and Cas9-sgRNA cleaved this locus with comparable efficiencies (Fig. 4e, 31.97% forNgAgo vs. 32.2% for Cas9). Next, we investigated whether NgAgo-gDNA ...
Protein design
引用批量引用
Genome editing revolutionize the creation of genetically modified pigs for modeling human diseases.
Jing Yao · Jiaojiao Huang · Jianguo Zhao
2016 · Human Genetics|被引数：3
The NgAgo-gDNA system did not require a PAM sequence, and could target GC-rich regions. Most of all, it had a low tolerance to guide-target mismatch, ...
引用下载批量引用
Replications, ridicule and a recluse: the controversy over NgAgo gene-editing intensifies.
David Cyranoski
2016 · Nature|被引数：3
In the paper, Han’s team reports using a wide variety of genetic sequences to guide one of these proteins,NgAgo, to edit eight different genes in human cells and ...
Genetics Genomics
引用批量引用
An alternative novel tool for DNA editing without target sequence limitation: the structure-guided nuclease.
Shu Xu · Shasha Cao · Bingjie Zou · Yunyun Yue · Chun Gu · Xin Chen · Pei Wang · Xiaohua Dong · Z…
2016 · Genome Biology|被引数：2
Engineered endonucleases are a powerful tool for editing DNA. However, sequence preferences may limit their application. We engineer a structure-guided endonuclease (SGN) composed of flap endonuclease-…
Bioinformatics Evolutionary biology Human genetics
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科学网—NgAgo 能够超越 CRISPR吗？——老外评论拾碎 ...
blog.sciencenet.cn/blog-295006-979015.html
NgAgo 能够超越 CRISPR吗？不止国内，有些老外也比较关注这个问题。世界上做基因组编辑方法和应用的实验室，差不多都有 ...
科学网—韩春雨 NgAgo 无 PAM 优势或被证明 - 岳东晓的博文
bbs.sciencenet.cn/blog-684007-1014872.html
根据上图，使用 NgAgo , 导引 gDNA 可以连续滑动延展，看不出有任何限制。NgAgo + gDNA 的精确定位功能，我再引用文章中的数据说明一下。针对斑马鱼的尾巴，下面 ...