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食药同源的药理毒理基础

已有 136 次阅读 2019-11-11 22:47 |个人分类:学术研究|系统分类:论文交流| 食药同源, homology, food, and, medicine

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Pharmacological and Toxicological Basis of Food and Drug Cognate

Jian Li1; Qiang Yang1; Xiaohui Zou2

1 Sichuan Technology & Business College, Chengdu, Sichuan, China

2 Sino-American Searle Research Center, Beijing, China

Objectives: This paper is to explore the scientific principles from the perspective of homology of food and medicine, especially the pharmacological and toxicological causes. Question: what conditions can be used to homologous of food and medicine? Which aspect of material, energy and information play a major role?

Methods: First of all, the corresponding research is carried out from the two aspects of clinical practice and basic theory. The former involves two types of practice cases. One is that food and drugs have the same direction, mainly the distinction between component proportion and quantity; the other is that food and medicine have the opposite effect, which is the essential difference, not only the composition, proportion and quantity of the substance, but also the function is extremely different. The latter involves a range of disciplines, physiology, pharmacology and toxicology of their concepts, principles, methods and examples that must be systematic combing. Furthermore, two major categories of actual cases are examined, one is direct, the typical case of life experience and clinical medicine; the other is indirect, that is, literature analysis and big data analysis. Finally, systematically compare and verify the three aspects of resistance, lesion and external sense. This method is characterized by these ways: a large probability case adopts the machine learning; a small probability case adopts the human-machine system; and exceptional case mainly plays an expert role.

Result: There are several aspects to its beneficial effects. First, a series of cases are summarized in practical experience, discussed in basic theory and supported by big data. This is far more advanced than the era of relying solely on cases. Furthermore, the related disciplines has laid a good foundation for the subsequent research, especially in combination with high-tech such as artificial intelligence era computer networks and others, to make a reasonable division of labor between human brain and computer. The advantage of efficiency cooperation can better combine the experience accumulated by Chinese medicine with the technology of Western medicine to apply to daily life needs. Finally, this subversion with the introduction of knowledge-based big production methods has greatly surpassed and systematically brought together the rational parts of the small-scale production methods that have continued to this day.

Conclusions: The significance lies in: the basic theoretical research has broadened the existing vision of pharmacology and toxicology; the clinical practical application has achieved a high degree of sharing experience, knowledge and capacity extension; daily life application is to let all kinds of people infinite; the upgrading of industrial structure is mainly to apply the latest research results of pharmacology and toxicology in the food industry and pharmaceutical industry, as well as upstream and downstream industries and supporting industries better resource configuration.

Acknowledgements: This work was supported by the Joint Project of Sino-American Searle Research Center in China (Grants No. 2018-2019-03).

Correspondence Author: Xiaohui Zou,[ http://orcid.org/0000-0002-5577-8245  ] Sino-American Searle Research Center, Beijing, China (E-mail: 949309225@qq.com)


Published in Basic & Clinical Pharmacology & Toxicology in 2019

https://publons.com/publon/27524384/

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ABSTRACTS 

 

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Abstracts

First published: 07 July 2019

 

https://doi.org/10.1111/bcpt.13266

001

Pharmacological and toxicological basis of food and drug cognate

Jian Li1; Qiang Yang1; Xiaohui Zou2

1Sichuan Technology & Business College, Chengdu, Sichuan, China; 2Sino‐American Searle Research Center, Beijing, China

Objectives: This paper is to explore the scientific principles from the perspective of homology of food and medicine, especially the pharmacological and toxicological causes. Question: what conditions can be used to homologous of food and medicine? Which aspect of material, energy and information play a major role?

Methods: First of all, the corresponding research is carried out from the two aspects of clinical practice and basic theory. The former involves two types of practice cases. One is that food and drugs have the same direction, mainly the distinction between component proportion and quantity; the other is that food and medicine have the opposite effect, which is the essential difference, not only the composition, proportion and quantity of the substance, but also the function is extremely different. The latter involves a range of disciplines, physiology, pharmacology and toxicology of their concepts, principles, methods and examples that must be systematic combing. Furthermore, two major categories of actual cases are examined, one is direct, the typical case of life experience and clinical medicine; the other is indirect, that is, literature analysis and big data analysis. Finally, systematically compare and verify the three aspects of resistance, lesion and external sense. This method is characterized by these ways: a large probability case adopts the machine learning; a small probability case adopts the human‐machine system; and exceptional case mainly plays an expert role.

Result: There are several aspects to its beneficial effects. First, a series of cases are summarized in practical experience, discussed in basic theory and supported by big data. This is far more advanced than the era of relying solely on cases. Furthermore, the related disciplines have laid a good foundation for the subsequent research, especially in combination with high‐tech such as artificial intelligence era computer networks and others, to make a reasonable division of labor between human brain and computer. The advantage of efficiency cooperation can better combine the experience accumulated by Chinese medicine with the technology of Western medicine to apply to daily life needs. Finally, this subversion with the introduction of knowledge‐based big production methods has greatly surpassed and systematically brought together the rational parts of the small‐scale production methods that have continued to this day.

Conclusions: The significance lies in: the basic theoretical research has broadened the existing vision of pharmacology and toxicology; the clinical practical application has achieved a high degree of sharing experience, knowledge and capacity extension; daily life application is to let all kinds of people infinite; the upgrading of industrial structure is mainly to apply the latest research results of pharmacology and toxicology in the food industry and pharmaceutical industry, as well as upstream and downstream industries and supporting industries better resource configuration.

Acknowledgements: This work was supported by the Joint Project of Sino‐American Searle Research Center in China (Grants No. 2018‐2019‐3).

Correspondence Author: Xiaohui Zou, Sino‐American Searle Research Center.

https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.13266 




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