加入药物所, 目前第一篇文章已经发表于ChemComm (Camb).

以天然产物异黄酮为起始化合物，经过化学修饰，制备了一系列新型的荧光分子骨架-AMHC，其在生物成像中表现出优于同发射光谱段的商业染料AMC的性能.

希望大家多多尝试采用AMHC类的荧光骨架进行研究。

http://pubs.rsc.org/en/content/articlelanding/2015/cc/c4cc06762b

Development of 3-Alkyl-6-Methoxy-7-Hydroxy-Chromone (AMHC) from Natural Isoflavones, a New Fluorescent Scaffold for Biological Imaging

Jianzhuang Miao^a,⊥, Huaqing Cui^a,⊥,*, Jing Jin^a, Fangfang Lai^a, Hui Wen^b, Xiang Zhang^b, Gian Filippo Ruda^c, Xiaoguang Chen^a, and Dali Yin^a,*

Starting from 7-hydroxyisoflavones, we developed a new class of fluorescent scaffold,3-Alkyl-6-Methoxy-7-Hydroxy-Chromone (AMHC, MW~205.19,  λ_ab~350 nm,  λ_em~450 nm)  via a trial and error process.  AMHCs have the advantages of being a small molecular moiety, having strong fluorescence in basic buffers, reasonablesolubility and stability, non-toxicity, and are conveniently linked to pharmacophores. AMHCs were successfully used in fluorescence microscopy imaging of cells and tissues.