Science——单细胞甲基化组揭示大脑神经元类型的保守性和特异性

Summary

1. High-throughput single-nucleus methylome sequencing (snmCseq) of mouse and human frontal cortex (FC) neurons.

2. Non-CG methylation (mCH) signatures identify distinct neuron populations in mouse and human FC.

3. Conserved and divergent neuron type–specific gene regulatory elements.

4. Gene body mCH and CG-DMRs conserved between mouse and human.