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Nature——微观结构学研究揭示突触囊泡融合的神经分子机制
Summary
1. Crystal structures of the Syt1–SNARE–Cpx–Syt1 complex.
2. Close-up views of the SNARE–Cpx–Syt1 tripartite interface.
3. Probing the interfaces between the SNARE complex and the Syt1 C2B domain by ITC.
4. Ca2+ triggering of release by Syt1 requires both the SNARE–Cpx–Syt1 and the Syt1–SNARE interfaces.
5. Unlocking and triggering the primed Syt1–SNARE–Cpx–Syt1 complex.
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