PNAs——TLR4参与腹隔核突触生理功能和成瘾行为调控

summary

1. Altered synaptic properties in NAc core of TLR4.KO mice.

2. Altered NAc core NMDAR pharmacological profile in TLR4.KO mice.

3. Impaired NMDAR-dependent LTD and intact group II mGluR LTD in the NAc core of TLR4.KO mice.

4. TLR4.KO mice exhibit attenuated drug reward learning without deficits in episodic memory or expression of anhedonia.