JCI——Nav1.9突变引起痛觉不敏感的电生理学机制

Abstract

1.NaV1.9 mutation in a family with insensitivity to pain.

2.Functional consequences of the NaV1.9 mutation L1302F.

3.Effects of L1302F on voltage dependences of activation and inactivation.

4.Effects of mutant channels on the RMP in small DRG neurons.

5.Effects of mutant channels on action potential properties.

6.Depolarization of RMP causes biphasic changes in the current threshold and attenuates the action potential amplitude.