Nature——微生物感染和TLR4信号通路激活可能引起脑海绵状血管畸形

Abstract

1.CCM formation is stimulated by GNB infection and
intravenous LPS injection.

2.CCM lesion formation requires endothelial TLR4/CD14
signalling.

3.Increased TLR4 or CD14 expression is associated with higher lesion number in familial CCM patients.

4.CCMs fail to form in most germ-free mice.

5.CCM susceptibility is associated with increased levels of Gram-negative Bacteroidetes s24-7.