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Neuron—科学家通过条件性敲除技术揭示Neurexins的突触整合功能

已有 3617 次阅读 2017-5-17 07:46 |个人分类:神经科学临床和基础|系统分类:观点评述

Neuron—科学家通过条件性敲除技术揭示Neurexins的突触整合功能

Abstract

1.Sparse Deletion of All Neurexins in the Inferior Olive Causes Retraction of Presynaptic Climbing Fibers from the Cerebellar Cortex

2.Global Pan-neurexin Deletions in the Inferior Olive Impair Presynaptic Climbing-Fiber Synaptic Transmission

3.Pv-Cre-Mediated Deletion of All Neurexins in Pv+ Interneurons Decreases the Density of Pv+ Inhibitory Synapses in the mPFC

4.Paired Recordings Reveal that Pv-Cre-Mediated Deletion of All Neurexins in Pv+ Interneurons Decreases Inhibitory Synaptic Transmission at Pyramidal Neuron Synapses of the mPFC Similar to the Synapse Density

5.Two-Photon Microscopy Reveals that Pv-Cre-Mediated Pan-neurexin Deletion in Pv+ Interneurons Does Not Alter Action Potential-Induced Ca2+ Influx into Presynaptic Terminals but Decreases the
Density of Presynaptic Axonal Boutons

6. SST-Cre-Mediated Pan-neurexin Deletion in SST+ Interneurons Induces Minor Changes in Synapse Numbers in the mPFC

7.SST-Cre-Mediated Pan-neurexin Deletion in SST+ Interneurons Impairs Evoked Synaptic Transmission as Monitored by Paired Recordings and Optogenetics

8.Two-Photon Microscopy Reveals that SST-Cre-Mediated Pan-neurexin Deletion in SST+ Interneurons Dramatically Decreased Action Potential-Evoked Presynaptic Ca2+ Transients in SST+ Interneurons