Nature Biotech—科学家使用多能干细胞培育出人类内耳器官

Abstract

1.Step-wise induction of otic-placode-like epithelia.

2.WNT signaling activation initiates self-organization and maturation of inner ear organoids containing vestibular-like hair cells.

3.Development of an ATOH1 fluorescent reporter hESC line for tracking hair cell induction.

4.hESC-derived hair cells have similar electrophysiological properties as native hair cells and form synapse-like contacts with sensory neurons.