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2008年临床医学领域热点论文
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检索2008年Web of Science分析得到25篇临床医学热点论文（当年引用最多的论文319次刊登的期刊为2007年影响因子排名第一的CA-A CANCER JOURNAL FOR CLINICIANS《临床癌症学报》），分别刊登在12种期刊上，其中NEW ENGLAND JOURNAL OF MEDICINE《新英格兰医学杂志》12篇、NATURE《自然》2篇、CIRCULATION《循环》2篇、CA-A CANCER JOURNAL FOR CLINICIANS《临床癌症学报》1篇、JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION《美国医学会志》、LANCET《柳叶刀》1篇、JOURNAL OF CLINICAL ONCOLOGY《临床肿瘤学杂志》1篇、PLOS MEDICINE1篇、LEUKEMIA《白血病》1篇、EUROPEAN RESPIRATORY JOURNAL《欧洲呼吸杂志》1篇、INTENSIVE CARE MEDICINE《抢救护理医学》1篇、CRITICAL CARE MEDICINE《危症监护医学》1篇， 第4、5、21、24、25篇为综述论文，第10篇为会议论文。
医学领域热点论文较多,2006-2008年高引用论文达到410篇,其中2008年当年的热点论文就有140多篇。
1、Title: Cancer statistics, 2008
Author(s): Jemal A, Siegel R, Ward E, et al.
Source: CA-A CANCER JOURNAL FOR CLINICIANS Volume: 58 Issue: 2 Pages: 71-96 Published: MAR-APR 2008
Times Cited: 319
Author(s): Jemal A, Siegel R, Ward E, et al.
Source: CA-A CANCER JOURNAL FOR CLINICIANS Volume: 58 Issue: 2 Pages: 71-96 Published: MAR-APR 2008
Times Cited: 319
Reprint Address: Jemal, A (reprint author), Amer Canc Soc, Dept Epidemiol & Surveillance Res, Atlanta, GA 30329 USA
2007年影响因子69.026（2007年影响因子排名第一）
2、Title: Reprogramming of human somatic cells to pluripotency with defined factors
Author(s): Park IH, Zhao R, West JA, et al.
Source: NATURE Volume: 451 Issue: 7175 Pages: 141-U1 Published: JAN 10 2008
Times Cited: 121
Author(s): Park IH, Zhao R, West JA, et al.
Source: NATURE Volume: 451 Issue: 7175 Pages: 141-U1 Published: JAN 10 2008
Times Cited: 121
Reprint Address: Daley, GQ (reprint author), Childrens Hosp, Div Pediat Hematol Oncol, 300 Longwood Ave, Boston, MA 02115 USA
2007年影响因子28.751
3、Title: Intensive insulin therapy and pentastarch resuscitation in severe sepsis
Author(s): Brunkhorst FM, Engel C, Bloos F, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 2 Pages: 125-139 Published: JAN 10 2008
Times Cited: 119
Author(s): Brunkhorst FM, Engel C, Bloos F, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 2 Pages: 125-139 Published: JAN 10 2008
Times Cited: 119
Reprint Address: Reinhart, K (reprint author), Univ Jena, Dept Anesthesiol & Intens Care Med, Erlanger Allee 101, D-07747 Jena, Germany
2007年影响因子52.589（2007年影响因子排名第二）
4、Title: Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
Author(s): Dellinger RP, Levy MM, Carlet JM, et al.
Source: CRITICAL CARE MEDICINE Volume: 36 Issue: 1 Pages: 296-327 Published: JAN 2008
Times Cited: 107
Author(s): Dellinger RP, Levy MM, Carlet JM, et al.
Source: CRITICAL CARE MEDICINE Volume: 36 Issue: 1 Pages: 296-327 Published: JAN 2008
Times Cited: 107
Reprint Address: Dellinger, RP (reprint author), Cooper Univ Hosp, Camden, NJ 08103 USA
2007年影响因子6.283
5、Title: Heart disease and stroke statistics - 2008 update - A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Author(s): Rosamond W, Flegal K, Furie K, et al.
Source: CIRCULATION Volume: 117 Issue: 4 Pages: E25-E146 Published: JAN 29 2008
Times Cited: 102
Author(s): Rosamond W, Flegal K, Furie K, et al.
Source: CIRCULATION Volume: 117 Issue: 4 Pages: E25-E146 Published: JAN 29 2008
Times Cited: 102
Reprint Address: Rosamond, W (reprint author), Amer Heart Assoc, 7272 Greenville Ave, Dallas, TX 75231 USA
2007年影响因子12.755
6、Title: Telmisartan, ramipril, or both in patients at high risk for vascular events
Author(s): Yusuf S, Teo KK, Pogue J, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 15 Pages: 1547-1559 Published: APR 10 2008
Times Cited: 90
Author(s): Yusuf S, Teo KK, Pogue J, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 15 Pages: 1547-1559 Published: APR 10 2008
Times Cited: 90
Reprint Address: Yusuf, S (reprint author), McMaster Univ, Populat Hlth Res Inst, Hamilton Hlth Sci, 237 Barton St E, Hamilton, ON L8L 2X2 Canada
2007年影响因子52.589（2007年影响因子排名第二）
7、Title: Selective publication of antidepressant trials and its influence on apparent efficacy
Author(s): Turner EH, Matthews AM, Linardatos E, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 3 Pages: 252-260 Published: JAN 17 2008
Times Cited: 79
Author(s): Turner EH, Matthews AM, Linardatos E, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 3 Pages: 252-260 Published: JAN 17 2008
Times Cited: 79
Reprint Address: Turner, EH (reprint author), Vet Affairs Med Ctr, Behav Hlth & Neurosci Div, P3MHDC,3710 SW US Vet Hosp Rd, Portland, OR 97239 USA
2007年影响因子52.589（2007年影响因子排名第二）
8、Title: Effects of intensive glucose lowering in type 2 diabetes
Author(s): Gerstein HC, Miller ME, Byington RP, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 24 Pages: 2545-2559 Published: JUN 12 2008
Times Cited: 75
Author(s): Gerstein HC, Miller ME, Byington RP, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 24 Pages: 2545-2559 Published: JUN 12 2008
Times Cited: 75
Reprint Address: Byington, RP (reprint author), Wake Forest Univ, Sch Med, Div Publ Hlth Sci, Med Ctr Blvd, Winston Salem, NC 27157 USA
2007年影响因子52.589（2007年影响因子排名第二）
9、Title: Simvastatin with or without ezetimibe in familial hypercholesterolemia
Author(s): Kastelein JJP, Akdim F, Stroes ESG, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 14 Pages: 1431-1443 Published: APR 3 2008
Times Cited: 72
Author(s): Kastelein JJP, Akdim F, Stroes ESG, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 14 Pages: 1431-1443 Published: APR 3 2008
Times Cited: 72
Reprint Address: Kastelein, JJP (reprint author), Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, Meibergdreef 9,POB 22660, NL-1100 DD Amsterdam, Netherlands
2007年影响因子52.589（2007年影响因子排名第二）
10、Title: Hydrocortisone therapy for patients with septic shock
Author(s): Sprung CL, Annane D, Keh D, et al.
Conference Information: 103rd International Conference of the American-Thoracic-Society, MAY 18-23, 2007 San Francisco, CA
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 2 Pages: 111-124 Published: JAN 10 2008
Times Cited: 70
Author(s): Sprung CL, Annane D, Keh D, et al.
Conference Information: 103rd International Conference of the American-Thoracic-Society, MAY 18-23, 2007 San Francisco, CA
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 2 Pages: 111-124 Published: JAN 10 2008
Times Cited: 70
Reprint Address: Sprung, CL (reprint author), Hadassah Hebrew Univ Med Ctr, Dept Anesthesiol & Crit Care Med, Gen Intens Care Unit, POB 12000, IL-91120 Jerusalem, Israel
2007年影响因子52.589（2007年影响因子排名第二）
11、Title: Effect of a multifactorial intervention on mortality in type 2 diabetes
Author(s): Gaede P, Lund-Andersen H, Parving HH, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 6 Pages: 580-591 Published: FEB 7 2008
Times Cited: 69
Author(s): Gaede P, Lund-Andersen H, Parving HH, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 6 Pages: 580-591 Published: FEB 7 2008
Times Cited: 69
Reprint Address: Pedersen, O (reprint author), Steno Diabet Ctr, DK-2820 Gentofte, Copenhagen Denmark
2007年影响因子52.589（2007年影响因子排名第二）
12、Title: KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
Author(s): Lievre A, Bachet JB, Boige V, et al.
Source: JOURNAL OF CLINICAL ONCOLOGY Volume: 26 Issue: 3 Pages: 374-379 Published: JAN 20 2008
Times Cited: 62
Author(s): Lievre A, Bachet JB, Boige V, et al.
Source: JOURNAL OF CLINICAL ONCOLOGY Volume: 26 Issue: 3 Pages: 374-379 Published: JAN 20 2008
Times Cited: 62
Reprint Address: Laurent-Puig, P (reprint author), Univ Paris 05, Inst Natl Sante & Rech Med, U775, F-75006 Paris, France
2007年影响因子15.484
13、Title:HLA-B*5701 screening for hypersensitivity to abacavir
Author(s): Mallal S, Phillips E, Carosi G, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 6 Pages: 568-579 Published: FEB 7 2008
Times Cited: 51
Author(s): Mallal S, Phillips E, Carosi G, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 6 Pages: 568-579 Published: FEB 7 2008
Times Cited: 51
Reprint Address: Mallal, S (reprint author), Murdoch Univ, Inst Immunol & Infect Dis, South St, Murdoch, WA 6150 Australia
2007年影响因子52.589（2007年影响因子排名第二）
14、Title: Treatment of hypertension in patients 80 years of age or older
Author(s): Beckett NS, Peters R, Fletcher AE, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 18 Pages: 1887-1898 Published: MAY 1 2008
Times Cited: 49
Author(s): Beckett NS, Peters R, Fletcher AE, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 18 Pages: 1887-1898 Published: MAY 1 2008
Times Cited: 49
Reprint Address: Beckett, NS (reprint author), Univ London Imperial Coll Sci Technol & Med, Div Med, Du Cane Rd, London W12 0NN, England
2007年影响因子52.589（2007年影响因子排名第二）
15、Title:A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Author(s): Thorgeirsson TE, Geller F, Sulem P, et al.
Source: NATURE Volume: 452 Issue: 7187 Pages: 638-U9 Published: APR 3 2008
Times Cited: 48
Author(s): Thorgeirsson TE, Geller F, Sulem P, et al.
Source: NATURE Volume: 452 Issue: 7187 Pages: 638-U9 Published: APR 3 2008
Times Cited: 48
Reprint Address: Thorgeirsson, TE (reprint author), deCODE Genet, IS-101 Reykjavik, Iceland
2007年影响因子28.751
16、Title: Initial severity and antidepressant benefits: A meta-analysis of data submitted to the food and drug administration
Author(s): Kirsch I, Deacon BJ, Huedo-Medina TB, et al.
Source: PLOS MEDICINE Volume: 5 Issue: 2 Pages: 260-268 Published: FEB 2008
Times Cited: 47
Author(s): Kirsch I, Deacon BJ, Huedo-Medina TB, et al.
Source: PLOS MEDICINE Volume: 5 Issue: 2 Pages: 260-268 Published: FEB 2008
Times Cited: 47
Reprint Address: Kirsch, I (reprint author), Univ Hull, Dept Psychol, Kingston Upon Hull HU6 7RX, N Humberside England
2007年影响因子12.601
17、Title: 2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction - A report of the American college of cardiology/American heart association task force on practice guidelines
Author(s): Antman EM, Hand M, Armstrong PW, et al.
Source: CIRCULATION Volume: 117 Issue: 2 Pages: 296-329 Published: JAN 15 2008
Times Cited: 46
Author(s): Antman EM, Hand M, Armstrong PW, et al.
Source: CIRCULATION Volume: 117 Issue: 2 Pages: 296-329 Published: JAN 15 2008
Times Cited: 46
Publisher: LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
2007年影响因子12.755
18、Title: Adjustable gastric banding and conventional therapy for type 2 diabetes - A randomized controlled trial
Author(s): Dixon JB, O'Brien PE, Playfair J, et al.
Source: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION Volume: 299 Issue: 3 Pages: 316-323 Published: JAN 23 2008
Times Cited: 44
Author(s): Dixon JB, O'Brien PE, Playfair J, et al.
Source: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION Volume: 299 Issue: 3 Pages: 316-323 Published: JAN 23 2008
Times Cited: 44
Reprint Address: Dixon, JB (reprint author), Monash Univ, Sch Med, Alfred Hosp, Ctr Obes Res & Educ, Melbourne, Vic 3004 Australia
2007年影响因子25.547
19、Title: Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial
Author(s): Besselink MGH, van Santvoort HC, Buskens E, et al.
Source: LANCET Volume: 371 Issue: 9613 Pages: 651-659 Published: FEB 23 2008
Times Cited: 42
Author(s): Besselink MGH, van Santvoort HC, Buskens E, et al.
Source: LANCET Volume: 371 Issue: 9613 Pages: 651-659 Published: FEB 23 2008
Times Cited: 42
Reprint Address: Gooszen, HG (reprint author), Univ Med Ctr Utrecht, Dept Surg, POB 85500,HP G04-228, NL-3508 GA Utrecht, Netherlands
2007年影响因子28.638
20、Title: Brief report: HLA-mismatched renal transplantation without maintenance immunosuppression
Author(s): Kawai T, Cosimi AB, Spitzer TR, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 4 Pages: 353-361 Published: JAN 24 2008
Times Cited: 38
Author(s): Kawai T, Cosimi AB, Spitzer TR, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 4 Pages: 353-361 Published: JAN 24 2008
Times Cited: 38
Reprint Address: Sachs, DH (reprint author), Massachusetts Gen Hosp, Transplantat Biol Res Ctr, 149 13th St, Charlestown, MA 02129 USA
2007年影响因子52.589（2007年影响因子排名第二）
21、Title: Classification and diagnosis of myeloproliferative neoplasms: The 2008 World Health Organization criteria and point-of-care diagnostic algorithms
Author(s): Tefferi A, Vardiman JW
Source: LEUKEMIA Volume: 22 Issue: 1 Pages: 14-22 Published: JAN 2008
Times Cited: 37
Author(s): Tefferi A, Vardiman JW
Source: LEUKEMIA Volume: 22 Issue: 1 Pages: 14-22 Published: JAN 2008
Times Cited: 37
Reprint Address: Tefferi, A (reprint author), Mayo Clin, Coll Med, Div Hematol, 200 1st St SW, Rochester, MN 55905 USA
2007年影响因子6.924
22、Title: Update on Avian Influenza A (H5N1) virus infection in humans
Author(s): Abdel-Ghafar AN, Chotpitayasunondh T, Gao ZC, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 3 Pages: 261-273 Published: JAN 17 2008
Times Cited: 37
Author(s): Abdel-Ghafar AN, Chotpitayasunondh T, Gao ZC, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 3 Pages: 261-273 Published: JAN 17 2008
Times Cited: 37
Reprint Address: Hayden, FG (reprint author), WHO, Dept Epidem & Pandem Alert & Response, Global Influenza Program, 20 Ave Appia, CH-1211 Geneva 27, Switzerland
2007年影响因子52.589（2007年影响因子排名第二）
23、Title:Capecitabine and oxaliplatin for advanced esophagogastric cancer
Author(s): Cunningham D, Starling N, Rao S, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 1 Pages: 36-46 Published: JAN 3 2008
Times Cited: 35
Author(s): Cunningham D, Starling N, Rao S, et al.
Source: NEW ENGLAND JOURNAL OF MEDICINE Volume: 358 Issue: 1 Pages: 36-46 Published: JAN 3 2008
Times Cited: 35
Reprint Address: Cunningham, D (reprint author), Royal Marsden Hosp Natl Hlth Serv Fdn Trust, Surrey, England
2007年影响因子52.589（2007年影响因子排名第二）
24、Title: Global strategy for asthma management and prevention: GINA executive summary
Author(s): Bateman ED, Hurd SS, Barnes PJ, et al.
Source: EUROPEAN RESPIRATORY JOURNAL Volume: 31 Issue: 1 Pages: 143-178 Published: JAN 2008
Times Cited: 35
Author(s): Bateman ED, Hurd SS, Barnes PJ, et al.
Source: EUROPEAN RESPIRATORY JOURNAL Volume: 31 Issue: 1 Pages: 143-178 Published: JAN 2008
Times Cited: 35
Reprint Address: Bateman, ED (reprint author), Univ Cape Town, Lung Inst, Groote Sch, POB 34560, ZA-7700 Cape Town, South Africa
2007年影响因子5.349
25、Title: Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
Author(s): Dellinger RP, Levy MM, Carlet JM, et al.
Source: INTENSIVE CARE MEDICINE Volume: 34 Issue: 1 Pages: 17-60 Published: JAN 2008
Times Cited: 35
Author(s): Dellinger RP, Levy MM, Carlet JM, et al.
Source: INTENSIVE CARE MEDICINE Volume: 34 Issue: 1 Pages: 17-60 Published: JAN 2008
Times Cited: 35
Reprint Address: Dellinger, RP (reprint author), Cooper Univ Hosp, 1 Cooper Pl,393 Dorrance, Camden, NJ 08103 USA
2007年影响因子4.623
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