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Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation
1 Fudan University Shanghai Cancer Center, Department of Oncology and Institute of Biomedical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China
2 State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China
3 Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Department of Biological Chemistry & Molecular Pharmacology, Brigham and Women’s Hospital, Boston, MA 02115, USA
The Cys-rich and DSBH domains form a compact catalytic domain
•TET2-dsDNA structure shows specific recognition of CpG dinucleotide by TET2
•5mC is inserted into the catalytic cavity through a base-flipping mechanism
•The catalytic cavity can accommodate 5mC and its derivatives for oxidation
Cell:复旦大学徐彦辉等人破解TET2-DNA复合物的晶体结构
徐彦辉 课题组:http://xtal.fudan.edu.cn/index.html
徐彦辉是施一公的博士后,他的弟子有名的还有颜宁,柴继杰等。施一公真是厉害,不仅仅本人做的那么好,还带出这么多。
第一作者Lulu Hu是我同级硕博直博生,恭喜她。
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