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Frontiers in Biology Volume 9, issue 4

已有 1841 次阅读 2014-11-26 09:38 |个人分类:Frontiers in Biology期刊进展|系统分类:论文交流


Cover Story

 The eukaryotic genome isfunctionally and spatially organized within the cell nucleus. How these spatialorganizations regulate genome function remains largely unclear. This review (pages 255-268) provides an overview on cytological observations of subnucleargene positioning, and summarizes recent findings onthe molecular mechanisms of gene positioning and genome function.

  Visualizing and tracking specific DNA sequences in the cell nucleus canprovide critical information on the spatiotemporal regulation of physiologicalprocesses including transcription, replication and repair. DNA fluorescence in situ hybridization(FISH) allowsdetermining the subnuclear localizations of specificDNA sequences infixed cells, while thelacO/lacI system and the m6A tracer technology enablethree-dimensional tracking of DNA elements inliving cells.The obtained information from these imaging assayscan be correlated with functional activities of these DNA elementsand with genome-wide analyses. Together these techniques willyield important advances in our understandings ofnuclear organizations,epigenetics and genome function.  

 The cover image in this issue illustrates currentcell imaging tools to detect subnucleargene positioning. DNA FISH, lacO/lacIsystem, and  m6A tracertechnology.(Seepages 255-268 by Nidhi Vishnoi and Jie Yao for more information)


Contents

 Volume 9 issue 4


Reviews

Gene positioning and genome function

Nidhi VISHNOI,Jie YAO()

FIB-0255-10313-JY.pdf


IRF4 and IRF8:governing the virtues of B lymphocytes

Vipul SHUKLA(),Runqing LU()

FIB-0269-10318-RQL.pdf


Research articles

Age-related peculiarities of change in content of free radical oxidation products in muscle during stress

Vadim V. DAVYDOV1,*(),Amjad HAMDALLAH2,Evgenya R. GRABOVETSKAYA3

http://www.frontiers-biology.org


Current trends of antibiotic resistance in clinical isolates of Staphylococcus aureus 

Kapil Dev SHARMA1,2,Rajendra Prasad SAINI1,Loganathan KARTHIK2,*()

http://www.frontiers-biology.org


Isolation and partial purification of fungal ligninolytic enzymes from the forest soil fungi isolated from Bhadra Wildlife Sanctuary

SHIVAKUMAR P. BANAKAR1,*(),B. THIPPESWAMY2

http://www.frontiers-biology.org


Bioactive compounds from Caulerpa racemosa as a potent larvicidal and antibacterial agent

Sowmya Rachannanavar NAGARAJ,Jabez William OSBORNE()

http://www.frontiers-biology.org


Isolation and characterization of tyrosinase produced by marine actinobacteria and its application in the removal of phenol from aqueous environment

Suki ROY1,Ishita DAS1,Minki MUNJAL1,Loganathan KARTHIK1,2,Gaurav KUMAR1,2,Sathish KUMAR1,Kokati Venkata Bhaskara RAO1,*()

http://www.frontiers-biology.org


Lucrative pectinase production by novel strain Pseudozyma sp. SPJ with statistical optimization techniques using agro-industrial residues

Sampriya SHARMA(),Jitender SHARMA,Rishi Pal MANDHAN

http://www.frontiers-biology.org


Apathy in Parkinson disease

Marina NODEL1,*(),Nikolay YAKHNO1,Anastasia MEDVEDEVA1,Michail KULIKOV2

http://www.frontiers-biology.org


Cognitive disorder in brain concussion
Vladimir ZAKHAROV1,*(),Ekaterina DROZDOVA2,Nikolay YAKHNO1

http://www.frontiers-biology.org





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上一篇:Frontiers in Biology, 2014, Volume 9 Issue 3
下一篇:Frontiers in Biology Volume 9, issue 5

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