These results imply that, early in their   evolutionary history, duplicate genes tend to be under moderate selective   constraints with the rate of amino acid substitution averaging about 43% of   the neutral expectation. The efficiency of purifying selection subsequently   increases approximately 10-fold, to the point at which only about 5% of amino   acid–changing mutations are able to rise to fixation.

这些结果表明，重复基因在其进化史的早期，往往处于中等选择性的约束下，氨基酸替代率平均约为43%，接近中性预期。纯化选择的效率随后增加约10倍，到只有约5%的改变氨基酸的突变能够被固定的程度。