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也起哄瞎谈诺贝尔奖 精选

已有 19991 次阅读 2014-10-11 07:07 |系统分类:科普集锦


这张图片是,几年前,国际诺贝尔运动会(International Association of Nobel Movement),对我所做的课题用了一个网页进行了科普报导介绍。我不懂俄文,但是其英文版见网页http://healthmad.com/conditions-and-diseases/the-bridge-resistance-secrets-of-the-rabbits/, 谷歌Google自动翻译一下,内容为:


电桥电阻:对兔子的秘密(The Bridge Resistance: Secrets of The Rabbits)

朊病毒 - 传染性病原体引起的牛,羊和人的复杂,至今无法治愈的疾病。然而,兔,狗或马对他们有着惊人的稳定。事实证明,“盐桥”整点。(Prions – infectious agents that cause complex and so far incurable disease of cows, sheep and humans. However, rabbits, dogs or horses to them are surprisingly stable. It turns out that the whole point of "salt bridges".)


朊病毒 - 传染性病原体引起的牛,羊和人的复杂,至今无法治愈的疾病。然而,兔,狗或马对他们有着惊人的稳定。事实证明,“盐桥”整点.(Prions – infectious agents that cause complex and so far incurable disease of cows, sheep and humans. However, rabbits, dogs or horses to them are surprisingly stable. It turns out that the whole point of “salt bridges”.)


朊病毒 - 危险和狡猾传染性病原体。它不是寄生蠕虫,并不简单,不是细菌而不是病毒 - 它们通常不应该被认为是活的。它们不含核酸:朊病毒是不正常的蛋白质多肽链的空间配置。和“品种”他们是非常不寻常的。与正常体蛋白的相互作用,以及它们改变其构象,使得危险的新的朊病毒。在可怕的“朊病毒的威胁,”我们被告知,在文章“100%被感染。”(Prions – the dangerous and cunning infectious agents. It is not parasitic worms, not simple, not bacteria and not viruses – they generally should not be considered alive. They contain no nucleic acids: Prions are abnormal proteins the polypeptide chain spatial configuration. And the “breed” they are extremely unusual. Interacting with a normal body protein, and they changing its conformation, making a  dangerous new prion. On the terrible “prion threat,” we were told in the article “100% infected.”)


朊蛋白最近被发现的,有人知道他们不少。但可以相信,它们可以负责的许多疾病的发展 - 不仅在人类。该系列的“豪斯医生”的球迷都熟悉的名字可怕的朊病毒疾病 - 疾病克雅氏病,库鲁病等广为人知的案件“疯牛”病(牛中牛海绵状脑病),它刚刚朊病毒的性质。(Prions have been discovered recently, is known about them quite a bit. But it is believed that they could be responsible for the development of a number of diseases – not only in humans. Fans of the series “House” are familiar names frightening prion diseases – disease Creutzfeldt-Jakob disease, Kuru disease, etc. Widely known cases of “mad cow” disease (bovine spongiform encephalopathy in cattle), which has just prion nature.)


有效的治疗方法仍然存在,但发现了一些具有朊病毒感染的意外性的动物。其中 - 和普通狗,兔子和马。这种稳定的性质仍然是一个绝对的谜。只有现在,由于在澳洲工作,生物学和数学家堡张,我们可以有事要告诉它。(Effective therapies are still there, but found a number of animals that have an unexpected resistance to prion infections. Among them – and ordinary dogs, rabbits and horses. The nature of such stability still remains an absolute mystery. Only now, thanks to working in Australia, biology and mathematics Jiapu Zhang, we can something to tell about it.)

科学家进行变化朊病毒从这些动物中分离出的空间构象的计算机模拟,如温度和pH。他的结论是朊病毒有抗药性的物种有一个不太灵活的结构,以稳定盐桥,其他链接。他们解决朊病毒结构域的位置,根据张“一样紧紧绷弦”。(Scientist conducted computer simulations of changes in spatial conformation of prions isolated from these animals, as the temperature and pH. He concluded that prions are resistant species have a less flexible structure to stabilize salt bridges, additional links. They fix the position of structural domains of prions, according to Zhang, “as tightly stretched bowstring.”)


该发现是特别有趣的,如果仅因为一旦医生给的方向上也能够创建治疗方案:空间形式通过建立在这些附加的盐桥危险的人类(和其它)朊病毒的稳定化。(This finding is particularly interesting if only because once doctors give a direction in which it is possible to create therapeutic solutions: stabilization of the spatial form dangerous to humans (and other) prion by creating in them additional salt bridges.)


上面这种现象仅仅只是说明脑科学是个十分重要的课题与研究方向,特别是老年痴呆神经退化性疾病。

<-- reported by "Moscow Technological Institute"



2014年诺贝尔奖
http://blog.sciencenet.cn/blog-498408-834670.html

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