一叶扁舟的博客分享 http://blog.sciencenet.cn/u/jinhejiang 崇山峻岭中的一滴露珠

博文

化学化工学院高分子课题组毕云梅教授在《Polymer Chemistry》杂志刊文

已有 3883 次阅读 2019-1-18 14:04 |个人分类:云师大研究|系统分类:论文交流

近日,云南师范大学化学化工学院高分子课题组毕云梅教授的学术论文“REnzyme triggered disassembly of amphiphilic linear-dendritic block copolymer micelles based on poly[N-(2-hydroxyethyl-l-glutamine)]”被英国皇家化学会数据库期刊《Polymer Chemistry》录用并发表。据了解,《Polymer Chemistry是高分子科学领域权威期刊,JCR一区,影响因子4.927。



Enzyme triggered disassembly of amphiphilic linear-dendritic block copolymer micelles based on poly[N-(2-hydroxyethyl-l-glutamine)]

作者:Qian, YY (Qian, Yangyang)1 ] You, D (You, Dan)1 ] Lin, F (Lin, Feng)1 ] Wei, JW (Wei, Junwu)1 ] Wang, YJ (Wang, Yujia)1 ] Bi, YM (Bi, Yunmei)1 ]

POLYMER CHEMISTRY

卷: 10

 

期: 1

 

页: 94-105

DOI: 10.1039/c8py01231h

出版年: JAN 7 2019

文献类型:Article

查看期刊影响力


摘要

Well-defined enzyme-responsive amphiphilic linear-dendritic diblock copolymers G-b-PHEG and bis-MPA-G(n)-b-PHEG (n = 1, 2) based on a hydrophilic linear block of poly(hydroxyethyl l-glutamine) (PHEG) and a hydrophobic dendron derived from cysteamine or an aliphatic polyester of 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) have been synthesized for the first time via a combination of the dendron-first strategy and the ring-opening polymerization of -amino acid N-carboxyanhydrides (NCA). The obtained copolymers G-b-PHEG and bis-MPA-G(n)-b-PHEG (n = 1, 2) were characterized by gel permeation chromatography (GPC), Fourier transfrom-infrared spectroscopy (FT-IR), and H-1 NMR spectroscopy. These amphiphilic copolymers are able to form nanospherical micelles or vesicles in aqueous solution as revealed by H-1 NMR analyses of the micelles in D2O, fluorescence spectroscopy, transmission electron microscopy (TEM) and particle size analysis. The self-assembled micelles show good enzyme-responsiveness, which can disassemble and release the encapsulated hydrophobic Nile red upon enzymatic activation. In vitro cytotoxicity studies indicate that the copolymers have good compatibility with SMMC-7721 cells. Such smart amphiphilic copolymers could potentially be applied for drug delivery systems and biosensors.

关键词

KeyWords Plus:MOLECULAR-WEIGHTDRUG-DELIVERYNANOPARTICLESCOMBINATIONRELEASEACIDPHPOLYMERIZATIONNANOCARRIERSDEGRADATION

作者信息

通讯作者地址: Bi, YM (通讯作者)

显示更多Yunnan Normal Univ, Coll Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China.


地址:

显示更多[ 1 ] Yunnan Normal Univ, Coll Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China


电子邮件地址:yunmeibi@hotmail.com

基金资助致谢

基金资助机构授权号
National Natural Science Foundation of China 

21264017 

21564017 

查看基金资助信息   

出版商

ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND

期刊信息

  • Impact Factor (影响因子rnal Citation Reports


类别 / 分类

研究方向:Polymer Science

Web of Science 类别:Polymer Science

查看更多数据字段




https://blog.sciencenet.cn/blog-454141-1157769.html

上一篇:云南师范大学的马铃薯在Nature Genetics上呈现了,一亩地只需2克种子
下一篇:2019年1月ESI高被引中收录云南师范大学论文增至35篇
收藏 IP: 183.224.72.*| 热度|

0

发表评论 评论 (0 个评论)

数据加载中...
扫一扫,分享此博文

全部作者的精选博文

Archiver|手机版|科学网 ( 京ICP备07017567号-12 )

GMT+8, 2024-3-19 14:21

Powered by ScienceNet.cn

Copyright © 2007- 中国科学报社

返回顶部