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近日,云南师范大学化学化工学院高分子课题组毕云梅教授的学术论文“REnzyme triggered disassembly of amphiphilic linear-dendritic block copolymer micelles based on poly[N-(2-hydroxyethyl-l-glutamine)]”被英国皇家化学会数据库期刊《Polymer Chemistry》录用并发表。据了解,《Polymer Chemistry》是高分子科学领域权威期刊,JCR一区,影响因子4.927。
Enzyme triggered disassembly of amphiphilic linear-dendritic block copolymer micelles based on poly[N-(2-hydroxyethyl-l-glutamine)]
作者:Qian, YY (Qian, Yangyang)[ 1 ] ; You, D (You, Dan)[ 1 ] ; Lin, F (Lin, Feng)[ 1 ] ; Wei, JW (Wei, Junwu)[ 1 ] ; Wang, YJ (Wang, Yujia)[ 1 ] ; Bi, YM (Bi, Yunmei)[ 1 ]
POLYMER CHEMISTRY
卷: 10
期: 1
页: 94-105
DOI: 10.1039/c8py01231h
出版年: JAN 7 2019
文献类型:Article
摘要
Well-defined enzyme-responsive amphiphilic linear-dendritic diblock copolymers G-b-PHEG and bis-MPA-G(n)-b-PHEG (n = 1, 2) based on a hydrophilic linear block of poly(hydroxyethyl l-glutamine) (PHEG) and a hydrophobic dendron derived from cysteamine or an aliphatic polyester of 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) have been synthesized for the first time via a combination of the dendron-first strategy and the ring-opening polymerization of -amino acid N-carboxyanhydrides (NCA). The obtained copolymers G-b-PHEG and bis-MPA-G(n)-b-PHEG (n = 1, 2) were characterized by gel permeation chromatography (GPC), Fourier transfrom-infrared spectroscopy (FT-IR), and H-1 NMR spectroscopy. These amphiphilic copolymers are able to form nanospherical micelles or vesicles in aqueous solution as revealed by H-1 NMR analyses of the micelles in D2O, fluorescence spectroscopy, transmission electron microscopy (TEM) and particle size analysis. The self-assembled micelles show good enzyme-responsiveness, which can disassemble and release the encapsulated hydrophobic Nile red upon enzymatic activation. In vitro cytotoxicity studies indicate that the copolymers have good compatibility with SMMC-7721 cells. Such smart amphiphilic copolymers could potentially be applied for drug delivery systems and biosensors.
关键词
KeyWords Plus:MOLECULAR-WEIGHT; DRUG-DELIVERY; NANOPARTICLES; COMBINATION; RELEASE; ACID; PH; POLYMERIZATION; NANOCARRIERS; DEGRADATION
作者信息
通讯作者地址: Bi, YM (通讯作者)
Yunnan Normal Univ, Coll Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China. |
地址:
[ 1 ] Yunnan Normal Univ, Coll Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China |
电子邮件地址:yunmeibi@hotmail.com
基金资助致谢
基金资助机构 | 授权号 |
---|---|
National Natural Science Foundation of China | 21264017 21564017 |
出版商
ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
期刊信息
Impact Factor (影响因子rnal Citation Reports
类别 / 分类
研究方向:Polymer Science
Web of Science 类别:Polymer Science
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