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我校王利勤教授课题组在国际著名杂志《有机化学快报》上发表文章

已有 590 次阅读 2017-9-12 13:14 |系统分类:人文社科

这是今年继续赵勇教授以通讯作者在该杂志发表天然药物化学以来的又一篇重要研究成果,这也预示着云南师范大学以陈业高、赵勇和王利勤教授领衔的天然药物化学研究逐渐进入了国内研究前沿阵地。

Four Hybrid Flavan-Chalcones, Caesalpinnone A Possessing a 10,11-Dioxatricyclic [5.3.3.0(1,6)]Tridecane-ridged System and Caesalpinflavans A-C from Caesalpinia enneaphylla

: (Zhang, Lan-Jun); (Bi, De-Wen); (Hu, Jiangmiao);  (Mu, Wei-Hua); (Li, Yuan-Ping);  (Xia, Guang-Hui); (Yang, Liu);  (Li, Xiao-Nian);  (Liang, Xue-Song); (Wang, Li-Qin).        

ORGANIC LETTERS

:19:16:4315-4318

DOI:10.1021/acs.orglett.7b01955

出版年:AUG 18 2017

摘要

Caesalpinnone A (1), an unprecedented hybrid of flavan and chalcone, possessing a 10,11-dioxatricyclic [5.3.3.0(1,6)]tridecane-bridged system, and caesalpinflavans A-C (2-4), three new hybrid flavan-chalcones, were isolated from the twigs and leaves of Caesalpinia enneaphylla. Their structures were elucidated by a combination of spectroscopic analyses and single-crystal X-ray diffraction. Caesalpinnone A showed the highest cytotoxicity against the HL-60, SMMC-7721, A-549, MCF-7, and SW-480 human tumor cell lines with an IC50 in the range of 0.54-0.87 mu M.

关键词

KeyWords Plus:CASSANE DITERPENES; SAPPAN

作者信息

通讯作者地址:        Wang, LQ (通讯作者)

Yunnan Normal Univ, Fac Chem & Chem Engn, Kunming 650050, Yunnan, Peoples R China.

地址:        

[ 1 ] Yunnan Normal Univ, Fac Chem & Chem Engn, Kunming 650050, Yunnan, Peoples R China

[ 2 ] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

电子邮件地址:lqwang@ynnu.edu.cn

基金资助致谢

基金资助机构

授权号

National Natural Science Foundation of China

31460085

查看基金资助信息  

出版商

AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA

类别 / 分类

研究方向:Chemistry

Web of Science 类别:Chemistry, Organic

文献信息

文献类型:Article

语种:English

入藏号:WOS:000408285600041

PubMed ID:28777586

ISSN:1523-7060

eISSN:1523-7052

期刊信息

Impact Factor (影响因子): Journal Citation Reports  

其他信息

IDS :FE5XW

Web of Science 核心合集中的 "引用的参考文献":        8

Web of Science 核心合集中的 "被引频次":        0









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