氢分子医学分享 http://blog.sciencenet.cn/u/孙学军 对氢气生物学效应感兴趣者。可合作研究:sunxjk@hotmail.com 微信 hydrogen_thinker

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氢水保护吸烟男性生育能力

已有 4901 次阅读 2013-11-14 20:41 |个人分类:氢气生理盐水|系统分类:科研笔记

氢水保护吸烟男性生育能力

抽烟有害健康,香烟烟雾中3000多类化合物,许多有害健康。尼古丁是香烟中最主要的有害物质,也经常被作为香烟危害的研究对象。吸烟不仅可以增加肺癌的发生,也严重危害男性性功能和生育能力。吸烟的危害和氧化应激增加的关系十分密切。

氢气具有选择性抗氧化能力,大量研究发现,氢气对各类氧化应激、炎症等相关疾病具有理想的治疗效果。对糖尿病男性性功能障碍有治疗作用,对动物睾丸缺血、反射损伤具有保护作用。氢气是否对慢性尼古丁处理引起的睾丸和精子氧化损伤是否具有保护作用,过去未见报道。

最近来自中国人民解放军海军总医院的学者研究发现,连续3月氢水对慢性尼古丁暴露导致的动物精子和睾丸氧化应激损伤具有理想的保护作用,而传统的抗氧化维生素,如VCVE均没有这样的作用。该研究将60只小鼠随机分成6组,分别是(1)对照组,(2)尼古丁组,每日4.5 mg/kg皮下注射3个月。(3)氢治疗组,每日皮下尼古丁注射,腹腔注射氢气饱和生理盐水。4)维生素C组(60 mg/kg/天ip)。(5)维生素E组(100 mg/kg/天ip)。


研究结果(见上)表明,氢气对吸烟导致的男性生育能力下降和睾丸损伤具有潜在的应用前景。该论文最近在线发表在Journal of assistedreproduction and genetics

Long-termtreatment of hydrogen-rich saline abates testicular oxidative stress induced bynicotine in mice.

Li S, LuD , Zhang Y , Zhang Y .

Department of Pharmacy, Navy General Hospital, No. 6Fucheng Road, Beijing, 100048, People's Republic of China.

Abstract
The present study was designed to test the hypothesis that long-term treatmentwith hydrogen-rich saline abated testicular oxidative stress induced bynicotine in mice. The effects of hydrogen-rich saline (6 ml/kg, i.p.),vitamin C (60 mg/kg, i.p.) and vitamin E (100 mg/kg, i.p.) onreproductive system and testicular oxidative levels in nicotine-treated(4.5 mg/kg, s.b.) mice were investigated. It was found that vitamin C andvitamin E attenuated serum oxidative level, but did not lower testicularoxidative levels in mice subjected to chronic nicotine treatment, and did notimprove the male reproductive damage and apoptosis induced by nicotine.Different from normal antioxidants, vitamin C and vitamin E, hydrogen-richsaline abated oxidative stress in testis, and protected againstnicotine-induced male reproductive damages. Our results first demonstrated thatlong-term treatment with hydrogen-rich saline attenuated testicular oxidativelevel and improved male reproductive function in nicotine-treated mice.

PMID: 24221909 [ - ]

文章全文见194837aop.pdf



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