氢分子医学分享 http://blog.sciencenet.cn/u/孙学军 对氢气生物学效应感兴趣者。可合作研究:sunxjk@hotmail.com 微信 hydrogen_thinker

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氢气治疗牛磺酸胆酸诱导的急性胰腺炎

已有 4082 次阅读 2013-8-5 09:57 |个人分类:氢气生理盐水|系统分类:科研笔记|关键词:胰腺炎| 胰腺炎

        急性胰腺炎急性胰腺炎是多种病因导致胰酶在胰腺内被激活后引起胰腺组织自身消化、水肿、出血甚至坏死的炎症反应。临床以急性上腹痛、恶心、呕吐、发热和血胰酶增高等为特点。病变程度轻重不等,轻者以胰腺水肿为主,临床多见,病情常呈自限性,预后良好,又称为轻症急性胰腺炎。少数重者的胰腺出血坏死,常继发感染、腹膜炎和休克等,病死率高,称为重症急性胰腺炎。临床病理常把急性胰腺炎分为水肿型和出血坏死型两种。

氧化应激是各种炎症性疾病共同的机制,在急性胰腺炎也必然十分重要。过去曾经有大量研究证明氢气对各类炎症和氧化应激损伤相关疾病具有理想的治疗作用,也有学者曾经报道氢气对精氨酸诱导的急性胰腺炎的治疗作用,但没有人观察和探讨过对牛磺酸胆酸诱导的急性胰腺炎的治疗效果。最近来自四川大学华西医院的学者开展了这方面的研究,文章发表在Evidence-BasedComplementary and Alternative Medicine


研究通过血清炎症因子、胰腺组织病理学分析、组织炎症因子基因表达和氧化应激相关指标,证明氢气生理盐水对这种疾病具有保护作用。研究提示氢气对急性胰腺炎具有潜在的治疗价值。

731932(2).pdf

http://www.hindawi.com/journals/ecam/2013/731932/

Oxidativestress plays an important role in the pathogenesis of acute pancreatitis (AP).As an ideal exterminator of poisonous free radicals, hydrogen can clearlyreduce the degree of oxidative damage caused by severe acute pancreatitis (SAP)and lessen the presence of inflammatory cytokines. The aim of this study was toinvestigate the effects and mechanism of hydrogen-rich saline on SAP in rats.Serum TNF-α, IL-6, and IL-18 and histopathological score in the pancreas werereduced after hydrogen-rich saline treatment. Malondialdehyde (MDA) andmyeloperoxidase (MPO) contents were obviously reduced, while superoxidedismutase (SOD) and glutathione (GSH) contents were increased afterhydrogen-rich saline treatment. The expression of mRNA of tumor necrosisfactor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1) in the pancreaswas reduced in hydrogen-rich saline treated group. In conclusion, intravenoushydrogen-rich saline injections could attenuate the severity of AP, probablyvia inhibiting the oxidative stress and reducing the presence of inflammatorymediators.

 

 




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