来自北京解放军总医院的一项研究发现，给去卵巢动物饮用氢气水可以有效预防骨质疏松，论文目前（2012年11月6日）在线发表在《英国药理学杂志》上。该课题组曾经报道氢气对失重引起的骨质疏松有预防作用，这应该是其系列研究中的一项。去卵巢手术多见于卵巢肿瘤，卵巢切除可导致雌性激素分泌障碍，导致一系列内分泌异常，当然可以采用激素取代疗法进行纠正，另外也可以引起骨质疏松，女性更年期后卵巢功能下降也会导致骨质疏松。针对这类骨质疏松的治疗并没有好的治疗和预防手段。许多研究发现，氧化应激也参与骨质疏松的形成（这显然应该是继发性改变），最近研究发现氢气作为一种良好的抗氧化物质，可以针对性中和羟基自由基和亚硝酸阴离子，从而产生抗氧化治疗作用。本研究工作的目的正是希望确定氢气是否具有预防卵巢切除后骨质疏松的作用。

将切除卵巢的动物喂养氢气水3月（水中氢气浓度1.3±0.2 mg/l，1.3 ppm）。然后采集血液和股骨和椎骨进行各类分析。研究结果发现，氢气水对切除卵巢动物的雌激素水平没有影响（不太可能有影响？），但可以避免股骨和椎骨骨质减少，包括骨矿物质量和矿物质密度。对卵巢切除后骨骼的极限负荷和刚度等机械应力（翻译可能不准确），骨小粱体积比、骨小粱数量、骨小粱厚度等影响均有保护作用。对氧化应激和炎症也产生抑制作用，如IL-6和TNFα的mRNA明显下降，不过股骨eNOS水平和血液NO水平增加。

研究结果说明，氢气水可以预防因为刺激素剥夺后氧化应激引起的骨质丢失。

Hydrogen water consumption prevents osteopenia in ovariectomized rats

Accumulating evidence indicates an important role of oxidative stress in the progression of osteoporosis. Recently it was demonstrated that hydrogen gas, as a novel antioxidant, could selectively reduce hydroxyl radicals and peroxynitrite anion to exert potent therapeutic antioxidant activity. The aim of present work was to investigate the effect of hydrogen water consumption on ovariectomy-induced osteoporosis. Ovariectomized rats were fed with hydrogen water (HW, 1.3±0.2 mg/l) for 3 months. Then, blood was collected and femur and vertebrae were removed for evaluation of the effect of HW on bone. HW consumption in ovariectomized rats had no significant effect on estrogen production, but prevented the reduction of bone mass including bone mineral content and bone mineral density in femur and vertebrae, and preserved mechanical strength including ultimate load, stiffness, and energy, and bone structure including trabecular bone volume fraction, trabecular number, and trabecular thickness in femur, and preserved mechanical strength including ultimate load and stiffness, and bone structure including trabecular bone volume fraction and trabecular number in vertebrae. In addition, treatment with HW abated oxidative stress and suppressed IL-6 and TNFα mRNA expressions in femur of ovariectomized rats; treatment with HW increased femur endothelial nitric oxide synthase (eNOS) activity and enhanced circulating nitric oxide (NO) level in ovariectomized rats.Hydrogen water consumption prevents osteopenia in ovariectomized rats possibly through the ablation of oxidative stress induced by estrogen withdrawal.