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氢气水可以治疗牙周病

已有 4366 次阅读 2011-10-15 11:24 |个人分类:饮用氢气水|系统分类:论文交流|关键词:xml office 牙周病 style black

 

氢气水可以治疗牙周病

Hydrogen-rich water attenuates experimental periodontitis in a rat model.pdf

这是首次将氢气用在口腔疾病的研究,这一研究的重要性是给我们提供了新的治疗疾病类型,但这一疾病的重要性是发病率特别高,大部分人都会在某一阶段存在一定的牙齿问题,而牙周病又占比较高的比例。这一疾病不仅适合进行临床研究,而且适合个人尝试。氢气水非常容易获得,对这个疾病,可以不需要饮用(但不限制),只需要漱口或含在口中就可以达到治疗目的。从个人的体会看,口腔疾病,例如口腔溃疡,直接漱口效果是非常理想的。希望很快将能看到人体试验的报告。

 

本研究论文刚刚发表,目前尚没有获得全文,只是根据摘要的理解,可能存在偏差,引用请注意查看全文。

http://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2011.01801.x/full

活性氧在牙周病的发展过程中发挥重要作用。因为氢气分子可以作为活性氧清除剂,我们检测了富氢气水对大鼠牙周病的治疗效果。将缝合线放在大鼠上颌骨臼齿周围4周诱导牙周病,动物给饮普通水或富氢气(对牙周病来讲,反复用氢气水漱口,或者用嘴含氢气更好,不过动物可不会漱口)。结果发现:与正常无牙周病大鼠比较,饮用普通水的牙周病大鼠血清中活性氧随着时间延长逐渐增加,同时齿槽骨出现中性颗粒细胞浸润和骨质丢失(大概是牙周病的典型表现)。饮用富氢气水牙周病大鼠血清中活性氧没有增加, 4周后齿槽骨8oHdG和硝基酪氨酸表达减少(氧化损伤指标),而且中性颗粒细胞浸润和骨质丢失也明显受到保护。而且与炎症有关的信号传导通路MAPK也受到明显抑制。

结论:氢气可以通过降低齿龈周围炎症氧化损伤预防牙周病。

Hydrogen-rich water attenuates experimental periodontitis in a rat model

Kenta Kasuyama, Takaaki Tomofuji, Daisuke Ekuni, Naofumi Tamaki, Tetsuji Azuma, Koichiro Irie, Yasumasa Endo Manabu Morita. Journal of Clinical Periodontology

 

Keywords:animal studies; antioxidants; hydrogen-rich water; oxidative stress; periodontitis

 

 

Abstract

Aim

 

Reactive oxygen species (ROS) contribute to the development of periodontitis. As molecular hydrogen can act as a scavenger of ROS, we examined the effects of treatment with hydrogen-rich water on a rat model of periodontitis.

Material & Methods

 

A ligature was placed around the maxillary molars for 4 weeks to induce periodontitis, and the animals were given drinking water with or without hydrogen-rich water.

Results

The rats with periodontitis which were treated with pure water showed a time-dependent increase in serum ROS level. Compared with the rats without periodontitis, the periodontitis-induced rats which were given pure water also showed polymorphonuclear leucocyte infiltration and alveolar bone loss at 4 weeks. Hydrogen-rich water intake inhibited an increase in serum ROS level and lowered expression of 8-hydroxydeoxyguanosine and nitrotyrosine in the periodontal tissue at 4 weeks. Such conditions prevented polymorphonuclear leucocyte infiltration and osteoclast differentiation following periodontitis progression. Furthermore, inflammatory signalling pathways, such as mitogen-activated protein kinases, were less activated in periodontal lesions from hydrogen-rich water-treated rats as compared with pure water-treated rats.

Conclusion

Consuming hydrogen-rich water might be beneficial in suppressing periodontitis progression by decreasing gingival oxidative stress.

 



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